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Energy Landscapes, Self-Assembly and Viruses

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dc.contributor.authorWales, DJ
dc.contributor.orcidWales, DJ [0000-0002-3555-6645]
dc.date.accessioned2017-10-03T07:39:27Z
dc.date.available2017-10-03T07:39:27Z
dc.date.issued2005
dc.date.updated2017-07-13T08:49:04Z
dc.description.abstract<jats:p>Phenomena such as protein folding, crystallisation, self-assembly, and the observation of magic number clusters in molecular beams are all the result of non-random searches. Analysis of the underlying potential energy surface may provide a unifying framework to explain how such events occur as the result of a guided exploration of the landscape. In particular, icosahedral shells composed of 12 pentagonal pyramids are found to be thermodynamically favourable and kinetically accessible when the pyramids are not too spiky and not too flat. Hence, viruses with icosahedral capsids not only minimise the genetic material required to encode the repeated subunits, but may also utilise the favourable properties of a potential energy surface that effectively directs self-assembly.</jats:p>
dc.description.versionPeer Reviewed
dc.identifier.citationD. J. Wales, “Energy Landscapes, Self-Assembly and Viruses,” Journal of Theoretical Medicine, vol. 6, no. 2, pp. 107-110, 2005. doi:10.1080/10273660500149570
dc.identifier.doi10.17863/CAM.13468
dc.identifier.eissn1607-8578
dc.identifier.issn1027-3662
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/267529
dc.language.isoeng
dc.language.rfc3066en
dc.publisherHindawi Limited
dc.publisher.urlhttp://dx.doi.org/10.1080/10273660500149570
dc.rightsAll Rights Reserved
dc.rights.holderCopyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved/
dc.subject4901 Applied Mathematics
dc.subject40 Engineering
dc.subject49 Mathematical Sciences
dc.subject4003 Biomedical Engineering
dc.subject7 Affordable and Clean Energy
dc.titleEnergy Landscapes, Self-Assembly and Viruses
dc.typeArticle
prism.publicationNameJournal of Theoretical Medicine
rioxxterms.versionofrecord10.1080/10273660500149570

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