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Relating the Biogenesis and Function of P Bodies in Drosophila to Human Disease.

Published version

Published version
Peer-reviewed

Repository DOI


Change log

Authors

Wilby, Elise L 

Abstract

Drosophila has been a premier model organism for over a century and many discoveries in flies have furthered our understanding of human disease. Flies have been successfully applied to many aspects of health-based research spanning from behavioural addiction, to dysplasia, to RNA dysregulation and protein misfolding. Recently, Drosophila tissues have been used to study biomolecular condensates and their role in multicellular systems. Identified in a wide range of plant and animal species, biomolecular condensates are dynamic, non-membrane-bound sub-compartments that have been observed and characterised in the cytoplasm and nuclei of many cell types. Condensate biology has exciting research prospects because of their diverse roles within cells, links to disease, and potential for therapeutics. In this review, we will discuss processing bodies (P bodies), a conserved biomolecular condensate, with a particular interest in how Drosophila can be applied to advance our understanding of condensate biogenesis and their role in disease.

Description

Peer reviewed: True


Funder: BBSRC DTP scholarship

Keywords

Drosophila, biomolecular condensates, processing bodies, translational regulation, Animals, Humans, Drosophila, Processing Bodies, Cell Nucleus, Cytoplasm, RNA

Journal Title

Genes (Basel)

Conference Name

Journal ISSN

2073-4425
2073-4425

Volume Title

14

Publisher

MDPI AG
Sponsorship
Wellcome Trust (200734/Z/16/Z)