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Synthesis of (E)-nitroolefins via decarboxylative nitration using t-butylnitrite (t-BuONO) and TEMPO.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Jana, Sandipan 
Saboo, Tapish 
Maji, Arun 
Maiti, Debabrata 

Abstract

Nitroolefins are usually synthesized using the Henry reaction. Here we report an alternative metal-free decarboxylative nitration protocol for the preparation of the nitroolefins from α,β-unsaturated carboxylic acids using t-butylnitrite (t-BuONO) and TEMPO. α,β-Unsaturated carboxylic acids bearing β-aromatic and β-heteroaromatic substituents gave (E)-nitroolefins exclusively under mild conditions. A radical based pathway has been proposed for this decarboxylative nitration reaction.

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Keywords

Alkenes, Carboxylic Acids, Cyclic N-Oxides, Decarboxylation, Nitrites, Nitro Compounds

Journal Title

Chem Commun (Camb)

Conference Name

Journal ISSN

1359-7345
1364-548X

Volume Title

49

Publisher

Royal Society of Chemistry (RSC)