Synthesis of (E)-nitroolefins via decarboxylative nitration using t-butylnitrite (t-BuONO) and TEMPO.
Accepted version
Peer-reviewed
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Repository DOI
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Authors
Manna, Srimanta https://orcid.org/0000-0002-3903-1256
Jana, Sandipan
Saboo, Tapish
Maji, Arun
Maiti, Debabrata
Abstract
Nitroolefins are usually synthesized using the Henry reaction. Here we report an alternative metal-free decarboxylative nitration protocol for the preparation of the nitroolefins from α,β-unsaturated carboxylic acids using t-butylnitrite (t-BuONO) and TEMPO. α,β-Unsaturated carboxylic acids bearing β-aromatic and β-heteroaromatic substituents gave (E)-nitroolefins exclusively under mild conditions. A radical based pathway has been proposed for this decarboxylative nitration reaction.
Description
Keywords
Alkenes, Carboxylic Acids, Cyclic N-Oxides, Decarboxylation, Nitrites, Nitro Compounds
Journal Title
Chem Commun (Camb)
Conference Name
Journal ISSN
1359-7345
1364-548X
1364-548X
Volume Title
49
Publisher
Royal Society of Chemistry (RSC)