On the Synthesis and Reactivity of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones
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Peer-reviewed
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Abstract
An improved, scalable synthetic route to the quinazolinone natural product 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one is reported. The applicability of this method to analogue synthesis and the synthesis of related natural products is explored. Finally, reactivity of the scaffold to a variety of electrophilic reagents, generating products stereoselectively, is reported.
Description
Journal Title
Synthesis
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Journal ISSN
0039-7881
1437-210X
1437-210X
Volume Title
49
Publisher
Thieme
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Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Charlotte Sutherell was funded by the Cambridge PhD Training Programme in Chemical Biology and Molecular Medicine. We gratefully acknowledge the EPSRC (SVL, Grant Nos. EP/K099494/1 and EP/K039520/1).