RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients.

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RA-MAP Consortium 

Rheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of early, drug naive RA, we performed comprehensive clinical and molecular profiling of 267 RA patients and 52 healthy vaccine recipients for up to 18 months to establish a high quality sample biobank including plasma, serum, peripheral blood cells, urine, genomic DNA, RNA from whole blood, lymphocyte and monocyte subsets. We have performed extensive multi-omic immune phenotyping, including genomic, metabolomic, proteomic, transcriptomic and autoantibody profiling. We anticipate that these detailed clinical and molecular data will serve as a fundamental resource offering insights into immune-mediated disease pathogenesis, progression and therapeutic response, ultimately contributing to the development and application of targeted therapies for RA.

Arthritis, Rheumatoid, Autoantibodies, Biological Specimen Banks, Humans, Monocytes, Proteomics, Vaccines
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Springer Science and Business Media LLC
Medical Research Council (MR/L016311/1)
Medical Research Council, 415 UK (An Immunological Toolkit for Clinical Application, grant number G1001518)