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The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Spreckley, Eleanor 
Rodriguez, Aina Fernandez 
Viscomi, Carlo 
Alamshah, Amin 

Abstract

Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of rodent feeding at the bout level in order to perform quantitative behavioural analysis. Analysing the different effects on feeding behaviour of peptide YY3-36 (PYY3-36), lithium chloride, glucagon-like peptide 1 (GLP-1), and leptin shows the precise behavioural changes caused by each anorectic agent. Our analysis demonstrates that the changes in feeding behaviour evoked by the anorectic agents investigated do not mimic the behaviour of well-fed animals and that the intermeal interval is influenced by fullness. We show how robust homeostatic control of feeding thwarts attempts to reduce food intake and how this might be overcome. In silico experiments suggest that introducing a minimum intermeal interval or modulating upper gut emptying can be as effective as anorectic drug administration.

Description

Keywords

Animals, Appetite Depressants, Eating, Feeding Behavior, Glucagon-Like Peptide 1, Homeostasis, Leptin, Male, Mice, Obesity, Peptide Fragments, Peptide YY, Rats

Journal Title

PLoS Biol

Conference Name

Journal ISSN

1544-9173
1545-7885

Volume Title

Publisher

Public Library of Science (PLoS)
Sponsorship
Biotechnology and Biological Sciences Research Council (BB/I001816/1, BB/J014575/1)
Diabetes UK (18/0005886)