Rational approaches towards inorganic and organometallic antibacterials.

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The occurrence of drug-resistant bacteria is drastically rising and new and effective antibiotic classes are urgently needed. However, most of the compounds in development are minor modifications of previously used drugs to which bacteria can easily develop resistance. The investigation of inorganic and organometallic compounds as antibiotics is an alternative approach that holds great promises due to the ability of such molecules to trigger metal-specific mechanisms of action, which results in lethal consequences for pathogens. In this review, a selection of concepts to rationally design inorganic and organometallic antibiotics is discussed, highlighting their advantages by comparing them to classical drug discovery programmes. The review concludes with a short perspective for the future of antibiotic drug development and the role metal-based compounds will play in the field.

antibiotics, antimicrobial photodynamic therapy (aPDT), metal-based compounds, rational design strategies, structure guided approaches, Anti-Bacterial Agents, Bacteria, Drug Discovery
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Biol Chem
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Walter de Gruyter GmbH
European Commission Horizon 2020 (H2020) Marie Sklodowska-Curie actions (789607)
This research was supported by the Marie Curie Research Grants Scheme, EU H2020 Framework Programme (H2020-MSCA-IF-2017, ID: 789607) and the Swiss National Science Foundation, the Early PostDoc.Mobility fellowship (P2ZHP2_164947).