Different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation.

Accepted version
Repository URI
https://www.repository.cam.ac.uk/handle/1810/284192
Repository DOI
https://doi.org/10.17863/CAM.31560
Files
Accepted version (183.25 KB)
Type
Article
Change log
Authors
Bailey, Peter SJ 
Hiltunen, J Kalervo  ORCID logo  https://orcid.org/0000-0002-3073-9602
Dieckmann, Carol L 
Kastaniotis, Alexander J  ORCID logo  https://orcid.org/0000-0003-3624-9214
Abstract

Paredes et al recently described Poldip2 as a novel regulator of mitochondrial lipoylation through stabilisation of ACSM1 (1). We have several concerns with their proposed model based on the following reasons.

Description
Keywords
Animals, Attitude, Hypoxia-Inducible Factor 1, Thioctic Acid
Journal Title
Proc Natl Acad Sci U S A
Conference Name
Journal ISSN
0027-8424
1091-6490
Volume Title
115
Publisher
Proceedings of the National Academy of Sciences
Publisher DOI
https://doi.org/10.1073/pnas.1804041115
Rights
http://www.rioxx.net/licenses/all-rights-reserved
Sponsorship
Wellcome Trust (102770/Z/13/Z)
Lister Institute of Preventive Medicine (unknown)
Wellcome Trust (205252/Z/16/Z)
Wellcome 102770/Z/13/Z and 205252/Z/16/Z Lister Institute RG87950
Collections
Cambridge University Research Outputs