Repository logo
 

Transmission of B.1.617.2 Delta variant between vaccinated healthcare workers

Simple item page
cam.depositDate2022-06-24
cam.issuedOnline2022-06-21
dc.contributor.authorKemp, Steven
dc.contributor.authorCheng, Mark TK
dc.contributor.authorHamilton, William L
dc.contributor.authorKamelian, Kimia
dc.contributor.authorChauhan, Himanshu
dc.contributor.authorDikid, Tanzin
dc.contributor.authorGogia, Hema
dc.contributor.authorLall, Hemlata
dc.contributor.authorPonnusamy, Kalaiarasan
dc.contributor.authorVerma, Kaptan
dc.contributor.authorDhar, Mahesh Shanker
dc.contributor.authorSingh, Manoj K
dc.contributor.authorDatta, Meena
dc.contributor.authorSoni, Namita
dc.contributor.authorMeena, Namonarayan
dc.contributor.authorMadan, Preeti
dc.contributor.authorSingh, Priyanka
dc.contributor.authorSharma, Ramesh
dc.contributor.authorSharma, Rajeev
dc.contributor.authorKabra, Sandhya
dc.contributor.authorKumar, Sattender
dc.contributor.authorKumari, Swati
dc.contributor.authorSharma, Uma
dc.contributor.authorChaudhary, Urmila
dc.contributor.authorSivasubbu, Sridhar
dc.contributor.authorScaria, Vinod
dc.contributor.authorWattal, Chand
dc.contributor.authorOberoi, JK
dc.contributor.authorRaveendran, Reena
dc.contributor.authorDatta, S
dc.contributor.authorDas, Saumitra
dc.contributor.authorMaitra, Arindam
dc.contributor.authorChinnaswamy, Sreedhar
dc.contributor.authorBiswas, Nidhan Kumar
dc.contributor.authorParida, Ajay
dc.contributor.authorRaghav, Sunil K
dc.contributor.authorPrasad, Punit
dc.contributor.authorSarin, Apurva
dc.contributor.authorMayor, Satyajit
dc.contributor.authorRamakrishnan, Uma
dc.contributor.authorPalakodeti, Dasaradhi
dc.contributor.authorSeshasayee, Aswin Sai Narain
dc.contributor.authorThangaraj, K
dc.contributor.authorBashyam, Murali Dharan
dc.contributor.authorDalal, Ashwin
dc.contributor.authorBhat, Manoj
dc.contributor.authorShouche, Yogesh
dc.contributor.authorPillai, Ajay
dc.contributor.authorAbraham, Priya
dc.contributor.authorPotdar, Varsha Atul
dc.contributor.authorCherian, Sarah S
dc.contributor.authorDesai, Anita Sudhir
dc.contributor.authorPattabiraman, Chitra
dc.contributor.authorManjunatha, MV
dc.contributor.authorMani, Reeta S
dc.contributor.authorUdupi, Gautam Arunachal
dc.contributor.authorNandicoori, Vinay
dc.contributor.authorTallapaka, Karthik Bharadwaj
dc.contributor.authorSowpati, Divya Tej
dc.contributor.authorSingh, Sujit
dc.contributor.authorRakshit, Partha
dc.contributor.authorAgrawal, Anurag
dc.contributor.authorIllingworth, Christopher JR
dc.contributor.authorGupta, Ravindra
dc.contributor.orcidKemp, Steven [0000-0001-7077-6793]
dc.contributor.orcidGupta, Ravindra [0000-0001-9751-1808]
dc.date.accessioned2022-06-27T23:30:32Z
dc.date.available2022-06-27T23:30:32Z
dc.date.issued2022-12
dc.date.updated2022-06-24T10:50:41Z
dc.description.abstract<jats:title>Abstract</jats:title><jats:p>Breakthrough infections with SARS-CoV-2 Delta variant have been reported in doubly-vaccinated recipients and as re-infections. Studies of viral spread within hospital settings have highlighted the potential for transmission between doubly-vaccinated patients and health care workers and have highlighted the benefits of high-grade respiratory protection for health care workers. However the extent to which vaccination is preventative of viral spread in health care settings is less well studied. Here, we analysed data from 118 vaccinated health care workers (HCW) across two hospitals in India, constructing two probable transmission networks involving six HCWs in Hospital A and eight HCWs in Hospital B from epidemiological and virus genome sequence data, using a suite of computational approaches. A maximum likelihood reconstruction of transmission involving known cases of infection suggests a high probability that doubly vaccinated HCWs transmitted SARS-CoV-2 between each other and highlights potential cases of virus transmission between individuals who had received two doses of vaccine. Our findings show firstly that vaccination may reduce rates of transmission, supporting the need for ongoing infection control measures even in highly vaccinated populations, and secondly we have described a novel approach to identifying transmissions that is scalable and rapid, without the need for an infection control infrastructure.</jats:p>
dc.identifier.doi10.17863/CAM.85788
dc.identifier.eissn2045-2322
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338376
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.departmentDepartment of Medicine
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleTransmission of B.1.617.2 Delta variant between vaccinated healthcare workers
dc.typeArticle
dcterms.dateAccepted2022-06-07
prism.issueIdentifier1
prism.number10492
prism.publicationDate2022
prism.publicationNameScientific Reports
prism.volume12
pubs.funder-project-idWellcome Trust (108082/A/15/Z)
pubs.funder-project-idRosetrees Trust (M807)
pubs.funder-project-idRosetrees Trust (M957)
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
pubs.licence-identifierapollo-deposit-licence-2-1
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41598-022-14411-7

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
s41598-022-14411-7.pdf
Size:
2.76 MB
Format:
Adobe Portable Document Format
Description:
Published version
Licence
https://creativecommons.org/licenses/by/4.0/
Download

Collections

Cambridge University Research Outputs