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From haematopoietic stem cells to complex differentiation landscapes

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The development of mature blood cells from haematopoietic stem cells has long served as a model for stem-cell research, with the haematopoietic differentiation tree being widely used as a model for the maintenance of hierarchically organized tissues. Recent results and new technologies have challenged the demarcations between stem and progenitor cell populations, the timing of cell-fate choices and the contribution of stem and multipotent progenitor cells to the maintenance of steady-state blood production. These evolving views of haematopoiesis have broad implications for our understanding of the functions of adult stem cells, as well as the development of new therapies for malignant and non-malignant haematopoietic diseases.



Adult Stem Cells, Animals, Cell Cycle, Cell Lineage, Cell Self Renewal, Gene Expression Profiling, Hematologic Diseases, Hematopoiesis, Hematopoietic Stem Cells, Humans, Multipotent Stem Cells, Single-Cell Analysis

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Springer Nature
Wellcome Trust (107630/Z/15/Z)
Biotechnology and Biological Sciences Research Council (BB/P002293/1)
Medical Research Council (G0900951)
Cancer Research Uk (None)
Isaac Newton Trust (MINUTE 646(M))
Leukaemia & Lymphoma Research (7060)
Leukaemia & Lymphoma Research (8061)
Leukaemia & Lymphoma Research (12029)
Leukaemia & Lymphoma Research (238)
Leukaemia & Lymphoma Research (6072)
Cancer Research UK (21762)
National Institute of Diabetes and Digestive and Kidney Diseases (R24DK106766)
Medical Research Council (MR/M008975/1)
Medical Research Council (MC_PC_12009)
Medical Research Council (G0900951/1)
E.L. is supported by a Sir Henry Dale fellowship from the Wellcome Trust (WT)/Royal Society. Research in the Laurenti and Gottgens laboratories is supported by the WT, CRUK, Bloodwise, MRC, BBSRC, NIH-NIDDK, and core support grants by the WT and MRC to the Wellcome-MRC Cambridge Stem Cell Institute.