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A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Poh, Jian-Siang 
Tran, Duc N 
Battilocchio, Claudio  ORCID logo  https://orcid.org/0000-0002-4601-8527
Hawkins, Joel M 
Ley, Steven V 

Abstract

A copper-catalyzed coupling reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups.

Description

Keywords

allenes, carbenes, copper, diazo compounds, flow chemistry, Alkadienes, Alkynes, Catalysis, Copper, Diazonium Compounds, Methane, Temperature

Journal Title

Angew Chem Int Ed Engl

Conference Name

Journal ISSN

1433-7851
1521-3773

Volume Title

54

Publisher

Wiley
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)