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Physical activity intensity, bout-duration, and cardiometabolic risk markers in children and adolescents.

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cam.issuedOnline2018-07-13
dc.contributor.authorTarp, Jakob
dc.contributor.authorChild, Abbey
dc.contributor.authorWhite, Tom
dc.contributor.authorWestgate, Kate
dc.contributor.authorBugge, Anna
dc.contributor.authorGrøntved, Anders
dc.contributor.authorWedderkopp, Niels
dc.contributor.authorAndersen, Lars B
dc.contributor.authorCardon, Greet
dc.contributor.authorDavey, Rachel
dc.contributor.authorJanz, Kathleen F
dc.contributor.authorKriemler, Susi
dc.contributor.authorNorthstone, Kate
dc.contributor.authorPage, Angie S
dc.contributor.authorPuder, Jardena J
dc.contributor.authorReilly, John J
dc.contributor.authorSardinha, Luis B
dc.contributor.authorvan Sluijs, Esther MF
dc.contributor.authorEkelund, Ulf
dc.contributor.authorWijndaele, Katrien
dc.contributor.authorBrage, Søren
dc.contributor.authorInternational Children’s Accelerometry Database (ICAD) Collaborators
dc.contributor.orcidTarp, Jakob [0000-0002-9186-7077]
dc.contributor.orcidWhite, Tom [0000-0001-8456-0803]
dc.contributor.orcidvan Sluijs, Esther MF [0000-0001-9141-9082]
dc.contributor.orcidEkelund, Ulf [0000-0003-2115-9267]
dc.date.accessioned2018-09-27T14:10:07Z
dc.date.available2018-09-27T14:10:07Z
dc.date.issued2018-09
dc.description.abstractOBJECTIVES: To determine the role of physical activity intensity and bout-duration in modulating associations between physical activity and cardiometabolic risk markers. METHODS: A cross-sectional study using the International Children's Accelerometry Database (ICAD) including 38,306 observations (in 29,734 individuals aged 4-18 years). Accelerometry data was summarized as time accumulated in 16 combinations of intensity thresholds (≥500 to ≥3000 counts/min) and bout-durations (≥1 to ≥10 min). Outcomes were body mass index (BMI, kg/m2), waist circumference, biochemical markers, blood pressure, and a composite score of these metabolic markers. A second composite score excluded the adiposity component. Linear mixed models were applied to elucidate the associations and expressed per 10 min difference in daily activity above the intensity/bout-duration combination. Estimates (and variance) from each of the 16 combinations of intensity and bout-duration examined in the linear mixed models were analyzed in meta-regression to investigate trends in the association. RESULTS: Each 10 min positive difference in physical activity was significantly and inversely associated with the risk factors irrespective of the combination of intensity and bout-duration. In meta-regression, each 1000 counts/min increase in intensity threshold was associated with a -0.027 (95% CI: -0.039 to -0.014) standard deviations lower composite risk score, and a -0.064 (95% CI: -0.09 to -0.038) kg/m2 lower BMI. Conversely, meta-regression suggested bout-duration was not significantly associated with effect-sizes (per 1 min increase in bout-duration: -0.002 (95% CI: -0.005 to 0.0005) standard deviations for the composite risk score, and -0.005 (95% CI: -0.012 to 0.002) kg/m2 for BMI). CONCLUSIONS: Time spent at higher intensity physical activity was the main determinant of variation in cardiometabolic risk factors, not bout-duration. Greater magnitude of associations was consistently observed with higher intensities. These results suggest that, in children and adolescents, physical activity, preferably at higher intensities, of any bout-duration should be promoted.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.30159
dc.identifier.eissn1476-5497
dc.identifier.issn0307-0565
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/282795
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1038/s41366-018-0152-8
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdolescent
dc.subjectBiomarkers
dc.subjectBlood Glucose
dc.subjectBlood Pressure
dc.subjectBody Mass Index
dc.subjectCardiovascular Diseases
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCross-Sectional Studies
dc.subjectExercise
dc.subjectHumans
dc.subjectInsulin
dc.subjectObesity
dc.subjectPhysical Conditioning, Human
dc.subjectRisk Factors
dc.subjectWaist Circumference
dc.titlePhysical activity intensity, bout-duration, and cardiometabolic risk markers in children and adolescents.
dc.typeArticle
dcterms.dateAccepted2018-06-03
prism.endingPage1650
prism.issueIdentifier9
prism.publicationDate2018
prism.publicationNameInt J Obes (Lond)
prism.startingPage1639
prism.volume42
pubs.funder-project-idMedical Research Council (MC_UU_12015/3)
pubs.funder-project-idMedical Research Council (MC_UU_12015/7)
pubs.funder-project-idWellcome Trust (087636/Z/08/Z)
pubs.funder-project-idEconomic and Social Research Council (ES/G007462/1)
pubs.funder-project-idMedical Research Council (MR/K023187/1)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idMedical Research Council (G0701877)
pubs.funder-project-idMedical Research Council (MC_U106179473)
rioxxterms.licenseref.startdate2018-09
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41366-018-0152-8

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