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A Multicentre UK Study of Outcomes for Locally Advanced Sinonasal Squamous Cell Carcinoma Treated with Adjuvant or Definitive Intensity-modulated Radiotherapy.

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cam.depositDate2021-12-23
cam.issuedOnline2021-06-17
cam.orpheus.success2022-01-04 - Embargo set during processing via Fast-track
dc.contributor.authorSlevin, F
dc.contributor.authorPan, S
dc.contributor.authorMistry, H
dc.contributor.authorDenholm, M
dc.contributor.authorShor, D
dc.contributor.authorOong, Z
dc.contributor.authorPrice, J
dc.contributor.authorJadon, R
dc.contributor.authorFleming, JC
dc.contributor.authorBarnett, G
dc.contributor.authorDixon, L
dc.contributor.authorPrestwich, R
dc.contributor.authorThomson, D
dc.contributor.orcidDenholm, Mary [0000-0001-5875-4487]
dc.date.accessioned2022-01-05T00:30:05Z
dc.date.available2022-01-05T00:30:05Z
dc.date.issued2021-10
dc.date.updated2021-12-23T11:33:43Z
dc.description.abstractAIMS: Sinonasal malignancies are rare; the most common histological subtype is squamous cell carcinoma (SCC). No randomised trial data exist to guide treatment decisions, with options including surgery, radiotherapy and chemotherapy. The role and sequence of a primary non-surgical approach in this disease remains uncertain. The aim of this study was to present treatment outcomes for a multicentre population of patients with locally advanced, stage IVa/b sinonasal SCC treated with radical-intent intensity-modulated radiotherapy, either definitively or postoperatively. MATERIALS AND METHODS: Consecutively treated patients with locally advanced, stage IVa/b sinonasal SCC at four UK oncology centres between January 2012 and December 2017 were retrospectively identified. Descriptive statistics and survival analyses were carried out. Univariable Cox regression analysis was carried out to evaluate the relationship between patient, disease and treatment factors and survival outcomes. RESULTS: In total, 56 patients with sinonasal SCC were included (70% maxillary sinus, 21% nasal cavity, 9% ethmoid/frontal sinus). Forty-one patients (73%) were treated by surgery/adjuvant (chemo)radiotherapy and 15 (27%) by definitive (chemo)radiotherapy. The median duration of follow-up was 3.8 years (interquartile range 2.0-4.7 years). Estimates for 5-year overall survival and progression-free survival were 30.2% and 24.2%, respectively. Local, regional and distant treatment failures were seen in 33%, 33% and 16% of patients, respectively. Univariable analysis revealed inferior progression-free survival for patients treated with neck dissection (hazard ratio 2.6, 95% confidence interval 1.2-6.1, P = 0.022) but no other significant association between the studied factors and survival outcomes. CONCLUSION: We show poor survival outcomes and high rates of locoregional treatment failure for patients with locally advanced stage IVa/b sinonasal SCC. There is a need to investigate improved treatments for this group of patients.
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.79384
dc.identifier.eissn1433-2981
dc.identifier.issn0936-6555
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/331935
dc.language.isoeng
dc.publisherElsevier
dc.publisher.departmentDepartment of Oncology
dc.publisher.urlhttp://dx.doi.org/10.1016/j.clon.2021.05.012
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectIntensity-modulated radiotherapy
dc.subjectlocally advanced
dc.subjectoutcomes
dc.subjectsinonasal squamous cell carcinoma
dc.subjectCarcinoma, Squamous Cell
dc.subjectDisease-Free Survival
dc.subjectHumans
dc.subjectParanasal Sinus Neoplasms
dc.subjectRadiotherapy, Adjuvant
dc.subjectRadiotherapy, Intensity-Modulated
dc.subjectRetrospective Studies
dc.subjectUnited Kingdom
dc.titleA Multicentre UK Study of Outcomes for Locally Advanced Sinonasal Squamous Cell Carcinoma Treated with Adjuvant or Definitive Intensity-modulated Radiotherapy.
dc.typeArticle
dcterms.dateAccepted2021-05-28
prism.endingPagee461
prism.issueIdentifier10
prism.publicationDate2021
prism.publicationNameClinical Oncology
prism.startingPagee450
prism.volume33
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
pubs.licence-identifierapollo-deposit-licence-2-1
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1016/j.clon.2021.05.012

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