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Identification of the first surrogate agonists for the G protein-coupled receptor GPR132


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Type

Article

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Authors

Shehata, MA 
Belcik Christensen, H 
Isberg, V 
Sejer Pedersen, D 

Abstract

We report the first pharmacological tool agonist for in vitro characterization of the orphan receptor GPR132, preliminary structure–activity relationships based on 32 analogs and a suggested binding mode from docking.

Description

Keywords

3404 Medicinal and Biomolecular Chemistry, 34 Chemical Sciences, 5.1 Pharmaceuticals

Journal Title

RSC Advances

Conference Name

Journal ISSN

2046-2069
2046-2069

Volume Title

5

Publisher

Royal Society of Chemistry (RSC)
Sponsorship
M.A.S. was supported by a research scholarship from the Drug Research Academy and Novo Nordisk A/S. D.E.G. and H.B.-O. gratefully acknowledge financial support by the Carlsberg Foundation. D.E.G. and D.S.P. gratefully acknowledges financial support by the Lundbeck Foundation. Nils Nyberg is acknowledged for help with NMR spectroscopy. NMR equipment used in this work was purchased via a grant from The Lundbeck Foundation (R77-A6742).