Lipid metabolism after mild cold stress in persons with a cervical spinal cord injury


Type
Article
Change log
Authors
Nishiyama, Kazunari 
Kamijo, Yoshi-Ichiro 
van der Scheer, Jan  ORCID logo  https://orcid.org/0000-0002-4368-0355
Kinoshita, Tokio 
Goosey-Tolfrey, Victoria 
Abstract

22 ABSTRACT 23 Study design Experimental study 24 Objectives To compare lipid metabolism in individuals with a cervical spinal cord injury (SCIC) 25 and able-bodied (AB) persons in response to mild cold stress. 26 Settings Laboratory of Wakayama Medical University, Japan. 27 Methods Nine males with SCIC and 11 AB wore a water-perfusion suit in a supine position. 28 Following 30-min rest thermoneutrality, the whole body was cooled by perfusing 25°C water 29 through the suit for 15-20 minutes (CS). Blood samples were collected before, immediately, and 60 30 (post-CS60) and 120 minutes after CS (post-CS120). Concentrations of serum free fatty acid 31 ([FFA]s), total ketone bodies ([tKB]s), insulin ([Ins]s) and plasma adrenaline ([Ad]p), noradrenaline 32 ([NA]p) and glucose ([Glc]p) were assessed. 33 Results [Ad]p in SCIC were lower than AB throughout the study (p=0.0002) and remained largely 34 unchanged in both groups. [NA]p increased after cold stress in AB only (p<0.0001; GxT p=0.006). 35 [FFA]s increased by 62% immediately after cold stress in SCIC (p=0.0028), without a difference 36 between groups (p=0.65). [tKB]s increased by 69% at post-CS60 and 132% at post-CS120 from the 37 start in SCIC with no differences between groups (p=0.54). [Glc]p and [Ins]s were reduced in SCIc 38 only (GxT p=0.003 and p=0.001, respectively). 39 Conclusion These data indicate that mild cold stress acutely elevates lipid and ketone body 40 metabolism in persons with SCIc, despite the presence of sympathetic dysfunction.

Description
Keywords
Male, Humans, Spinal Cord Injuries, Cervical Cord, Lipid Metabolism, Cold-Shock Response, Water
Journal Title
Spinal Cord
Conference Name
Journal ISSN
1362-4393
1476-5624
Volume Title
Publisher
Springer Nature [academic journals on nature.com]