A 5700 year-old human genome and oral microbiome from chewed birch pitch

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dc.contributor.authorJensen, Theis Z. T.
dc.contributor.authorNiemann, Jonas
dc.contributor.authorIversen, Katrine Højholt
dc.contributor.authorFotakis, Anna K.
dc.contributor.authorGopalakrishnan, Shyam
dc.contributor.authorVågene, Åshild J.
dc.contributor.authorPedersen, Mikkel Winther
dc.contributor.authorSinding, Mikkel-Holger S.
dc.contributor.authorEllegaard, Martin R.
dc.contributor.authorAllentoft, Morten E.
dc.contributor.authorLanigan, Liam T.
dc.contributor.authorTaurozzi, Alberto J.
dc.contributor.authorNielsen, Sofie Holtsmark
dc.contributor.authorDee, Michael W.
dc.contributor.authorMortensen, Martin N.
dc.contributor.authorChristensen, Mads C.
dc.contributor.authorSørensen, Søren A.
dc.contributor.authorCollins, Matthew J.
dc.contributor.authorGilbert, M. Thomas P.
dc.contributor.authorSikora, Martin
dc.contributor.authorRasmussen, Simon
dc.contributor.authorSchroeder, Hannes
dc.contributor.orcidJensen, Theis Z. T. [0000-0002-7166-7975]
dc.contributor.orcidIversen, Katrine Højholt [0000-0002-7134-7672]
dc.contributor.orcidFotakis, Anna K. [0000-0002-4585-4662]
dc.contributor.orcidGopalakrishnan, Shyam [0000-0002-2004-6810]
dc.contributor.orcidPedersen, Mikkel Winther [0000-0002-7291-8887]
dc.contributor.orcidSinding, Mikkel-Holger S. [0000-0003-1371-219X]
dc.contributor.orcidEllegaard, Martin R. [0000-0001-5777-091X]
dc.contributor.orcidMortensen, Martin N. [0000-0002-8914-9463]
dc.contributor.orcidGilbert, M. Thomas P. [0000-0002-5805-7195]
dc.contributor.orcidSikora, Martin [0000-0003-2818-8319]
dc.contributor.orcidRasmussen, Simon [0000-0001-6323-9041]
dc.contributor.orcidSchroeder, Hannes [0000-0002-6743-0270]
dc.date.accessioned2020-12-22T18:55:53Z
dc.date.available2020-12-22T18:55:53Z
dc.date.issued2019-12-17
dc.date.submitted2019-06-17
dc.date.updated2020-12-22T18:55:53Z
dc.description.abstractAbstract: The rise of ancient genomics has revolutionised our understanding of human prehistory but this work depends on the availability of suitable samples. Here we present a complete ancient human genome and oral microbiome sequenced from a 5700 year-old piece of chewed birch pitch from Denmark. We sequence the human genome to an average depth of 2.3× and find that the individual who chewed the pitch was female and that she was genetically more closely related to western hunter-gatherers from mainland Europe than hunter-gatherers from central Scandinavia. We also find that she likely had dark skin, dark brown hair and blue eyes. In addition, we identify DNA fragments from several bacterial and viral taxa, including Epstein-Barr virus, as well as animal and plant DNA, which may have derived from a recent meal. The results highlight the potential of chewed birch pitch as a source of ancient DNA.
dc.identifier.doi10.17863/CAM.62530
dc.identifier.eissn2041-1723
dc.identifier.others41467-019-13549-9
dc.identifier.other13549
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/315423
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectArticle
dc.subject/631/208/212/2142
dc.subject/631/208/457
dc.subject/631/208/514/1948
dc.subject/706/689/19/27
dc.subject/45/23
dc.subjectarticle
dc.titleA 5700 year-old human genome and oral microbiome from chewed birch pitch
dc.typeArticle
dcterms.dateAccepted2019-11-15
prism.issueIdentifier1
prism.publicationNameNature Communications
prism.volume10
pubs.funder-project-idVillum Fonden (Villum Foundation) (22917)
pubs.funder-project-idEC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) (649307, 676154)
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41467-019-13549-9
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