Repository logo
 

Sequential enhancer state remodelling defines human germline competence and specification

Accepted version
Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/334690

Repository DOI

https://doi.org/10.17863/CAM.82108
Thumbnail Image

Files

Accepted version (45.29 MB)
 Supporting information (2.51 MB)
 Supporting information (657.27 KB)

Type

Article

Change log

Authors

Abstract

Germline-soma segregation is a fundamental event during mammalian embryonic development. Here we establish the epigenetic principles of human primordial germ cell (hPGC) development using in vivo hPGCs and stem cell models recapitulating gastrulation.

Description

Keywords

Animals, Cell Differentiation, Embryonic Development, Endoderm, Gastrulation, Gene Expression Regulation, Developmental, Germ Cells, Humans, Mammals

Journal Title

Nature Cell Biology

Conference Name

Journal ISSN

1465-7392
1476-4679

Volume Title

Publisher

Nature Research

Publisher DOI

https://doi.org/10.1038/s41556-022-00878-z

Rights and licensing

All rights reserved
Except where otherwised noted, this item's license is described as All rights reserved
Sponsorship
Wellcome Trust (109146/Z/15/Z)
Wellcome Trust (096738/Z/11/Z)
Wellcome Trust (203831/Z/16/Z)
Wellcome Trust (209475/Z/17/Z)
Medical Research Council (MR/P009948/1)
BBSRC (BB/T01346X/1)
Wellcome Trust PhD studentship RG86341/PRZI/045 Aracely Castillo-Venzor Wellcome Trust PhD studentship (109146/Z/15/Z) Dawei Sun

Collections

University of Cambridge Research Outputs (Articles and Conferences)