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HIV and Vertebral Fractures: a Systematic Review and Metanalysis.

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cam.issuedOnline2018-05-18
dc.contributor.authorIlha, Thales ASH
dc.contributor.authorComim, Fabio V
dc.contributor.authorCopes, Rafaela M
dc.contributor.authorCompston, Juliet E
dc.contributor.authorPremaor, Melissa O
dc.contributor.orcidComim, Fabio V [0000-0002-2726-233X]
dc.contributor.orcidPremaor, Melissa O [0000-0002-0770-9202]
dc.date.accessioned2018-11-07T00:30:25Z
dc.date.available2018-11-07T00:30:25Z
dc.date.issued2018-05-18
dc.description.abstractThe survival of HIV-infected patients has increased with the advent of antiretroviral therapy with the emergence of new comorbidities. Vertebral fracture is a manifestation of reduced bone strength and osteoporosis. This study aims to assess the frequency of spine fractures in HIV-positive men and women aged over 18 years. We performed a systematic review of randomized controlled trials, cohort studies, cross-sectional studies, and case-control studies. Studies that evaluated morphometric and/or clinical vertebral fracture were included. In total 488 studies were found, of which 53 had their full texts evaluated. A total of 85,411 HIV positive individuals were identified in 26 studies. The meta-analysis of the prevalence of vertebral fractures included 12 studies with 10,593 subjects. The prevalence was 11.1% [95% confidence interval (95% CI) 4.5%, 25.0%, I2 98.2% p < 0.00001]. When we evaluated independently studies of clinical vertebral fracture and morphometric vertebral fracture, the prevalence was 3.9% (95% CI 0.9, 15.8, I2 96.4% p < 0.00001) and 20.2% (95% CI 15.7%, 25.6%, I2 69.9% p = 0.003) respectively. HIV-infected individuals had an odds ratio of vertebral fractures of 2.3 (95% CI 1.37, 3.85, I2 98.2% p < 0.00001) when compared with HIV-uninfected patients (n = 9 studies). In conclusion, HIV-positive subjects had a higher risk of vertebral fractures when compared with HIV-negative subjects.
dc.format.mediumElectronic
dc.identifier.doi10.17863/CAM.32052
dc.identifier.eissn2045-2322
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284679
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1038/s41598-018-26312-9
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCase-Control Studies
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHIV Infections
dc.subjectHumans
dc.subjectMale
dc.subjectOdds Ratio
dc.subjectPrevalence
dc.subjectRandomized Controlled Trials as Topic
dc.subjectSpinal Fractures
dc.titleHIV and Vertebral Fractures: a Systematic Review and Metanalysis.
dc.typeArticle
dcterms.dateAccepted2018-05-09
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameSci Rep
prism.startingPage7838
prism.volume8
rioxxterms.licenseref.startdate2018-05-18
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41598-018-26312-9

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