This repository holds the research output of members of the University of Cambridge. It is delivered and managed by the University Library's Office of Scholarly Communication team.

  • Development of stapled peptides targeting the Ral GTPases 

    Hurd, Catherine
    The ras genes are the most commonly mutated oncogenes in human cancers, with mutations occurring in approximately 20% of human tumours. However, more than 30 years of attempts to target Ras proteins therapeutically have ...
  • Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB 

    Holliday, Holly; Roden, Daniel; Junankar, Simon; Wu, Sunny Z; Baker, Laura A; Krisp, Christoph; Chan, Chia-Ling et al. (2021-01)
  • Abundancy of polymorphic CGG repeats in the human genome suggest a broad involvement in neurological disease 

    Annear, Dale J.; Vandeweyer, Geert; Elinck, Ellen; Sanchis-Juan, Alba; French, Courtney E.; Raymond, Lucy; Kooy, R. Frank (Nature Publishing Group UK, 2021-01-28)
    Abstract: Expanded CGG-repeats have been linked to neurodevelopmental and neurodegenerative disorders, including the fragile X syndrome and fragile X-associated tremor/ataxia syndrome (FXTAS). We hypothesized that as of ...
  • Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women 

    Jones, Garan; Trajanoska, Katerina; Santanasto, Adam J.; Stringa, Najada; Kuo, Chia-Ling; Atkins, Janice L.; Lewis, Joshua R. et al. (Nature Publishing Group UK, 2021-01-28)
    Abstract: Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study meta-analysis of 256,523 Europeans aged 60 years and ...

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