Apollo Home

This repository holds the research output of members of the University of Cambridge. It is delivered and managed by the University Library's Open Research Systems team.

Select a community to browse its collections.

School of Arts and Humanities

School of Clinical Medicine

School of Technology

School of the Biological Sciences

School of the Humanities and Social Sciences

School of the Physical Sciences

Colleges

Other Communities

A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function.

Hentschel, Andreas; Meyer, Nancy; Kohlschmidt, Nicolai; Groß, Claudia; Sickmann, Albert; Schara-Schmidt, Ulrike; Förster, FabianTöpf, AnaChristiansen, JonHorvath, RitaVorgerd, MatthiasThompson, RachelPolavarapu, KiranLochmüller, HannsPreusse, CorinnaHannappel, LuisSchänzer, AnneGrüneboom, AnikaGangfuß, AndreaRoos, Andreas et al. (Springer Science and Business Media LLC, 2023-05)

PPP1R21 acts as a co-factor for protein phosphatase 1 (PP1), an important serine/threonine phosphatase known to be essential for cell division, control of glycogen metabolism, protein synthesis, and muscle contractility. ...
Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics

Zhang, Danyang; Lape, Remigijus; Shaikh, Saher A; Kohegyi, Bianka K; Watson, Jake F; Cais, Ondrej; Nakagawa, TerunagaGreger, Ingo H et al. (Springer Science and Business Media LLC, 2023-03-25)

<jats:title>Abstract</jats:title><jats:p>AMPA glutamate receptors (AMPARs) mediate excitatory neurotransmission throughout the brain. Their signalling is uniquely diversified by brain region-specific auxiliary subunits, ...
Healthy Cities, A comprehensive dataset for environmental determinants of health in England cities

Han, Zhenyu; Xia, Tong; Xi, Yanxin; Li, Yong (Nature Publishing Group UK, 2023-03-25)

This paper presents a fine-grained and multi-sourced dataset for environmental determinants of health collected from England cities. We provide health outcomes of citizens covering physical health (COVID-19 cases, asthma ...
Calibrating the Dice Loss to Handle Neural Network Overconfidence for Biomedical Image Segmentation.

Yeung, Michael; Rundo, Leonardo; Nan, Yang; Sala, Evis; Schönlieb, Carola-Bibiane; Yang, Guang (Springer Science and Business Media LLC, 2022-12-06)

The Dice similarity coefficient (DSC) is both a widely used metric and loss function for biomedical image segmentation due to its robustness to class imbalance. However, it is well known that the DSC loss is poorly calibrated, ...

Read the Unlocking Research blog

Apollo - University of Cambridge Repository

Communities

Recently Added

A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function.

Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics

Healthy Cities, A comprehensive dataset for environmental determinants of health in England cities

Calibrating the Dice Loss to Handle Neural Network Overconfidence for Biomedical Image Segmentation.

Apollo - University of Cambridge Repository

Communities

Recently Added

A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function. ﻿

Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics ﻿

Healthy Cities, A comprehensive dataset for environmental determinants of health in England cities ﻿

Calibrating the Dice Loss to Handle Neural Network Overconfidence for Biomedical Image Segmentation. ﻿

A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function.

Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics

Healthy Cities, A comprehensive dataset for environmental determinants of health in England cities

Calibrating the Dice Loss to Handle Neural Network Overconfidence for Biomedical Image Segmentation.