This repository holds the research output of members of the University of Cambridge. It is delivered and managed by the University Library's Open Research Systems team.

  • A Homozygous PPP1R21 Splice Variant Associated with Severe Developmental Delay, Absence of Speech, and Muscle Weakness Leads to Activated Proteasome Function. 

    Hentschel, Andreas; Meyer, Nancy; Kohlschmidt, Nicolai; Groß, Claudia; Sickmann, Albert; Schara-Schmidt, Ulrike; Förster, Fabian et al. (Springer Science and Business Media LLC, 2023-05)
    PPP1R21 acts as a co-factor for protein phosphatase 1 (PP1), an important serine/threonine phosphatase known to be essential for cell division, control of glycogen metabolism, protein synthesis, and muscle contractility. ...
  • Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics 

    Zhang, Danyang; Lape, Remigijus; Shaikh, Saher A; Kohegyi, Bianka K; Watson, Jake F; Cais, Ondrej; Nakagawa, Terunaga et al. (Springer Science and Business Media LLC, 2023-03-25)
    <jats:title>Abstract</jats:title><jats:p>AMPA glutamate receptors (AMPARs) mediate excitatory neurotransmission throughout the brain. Their signalling is uniquely diversified by brain region-specific auxiliary subunits, ...
  • Healthy Cities, A comprehensive dataset for environmental determinants of health in England cities 

    Han, Zhenyu; Xia, Tong; Xi, Yanxin; Li, Yong (Nature Publishing Group UK, 2023-03-25)
    This paper presents a fine-grained and multi-sourced dataset for environmental determinants of health collected from England cities. We provide health outcomes of citizens covering physical health (COVID-19 cases, asthma ...
  • Calibrating the Dice Loss to Handle Neural Network Overconfidence for Biomedical Image Segmentation. 

    Yeung, Michael; Rundo, Leonardo; Nan, Yang; Sala, Evis; Schönlieb, Carola-Bibiane; Yang, Guang (Springer Science and Business Media LLC, 2022-12-06)
    The Dice similarity coefficient (DSC) is both a widely used metric and loss function for biomedical image segmentation due to its robustness to class imbalance. However, it is well known that the DSC loss is poorly calibrated, ...

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