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  Development of stapled peptides targeting the Ral GTPases 

  Hurd, Catherine

  The ras genes are the most commonly mutated oncogenes in human cancers, with mutations occurring in approximately 20% of human tumours. However, more than 30 years of attempts to target Ras proteins therapeutically have ...
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  Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB 

  Holliday, Holly; Roden, Daniel; Junankar, Simon; Wu, Sunny Z; Baker, Laura A; Krisp, Christoph; Chan, Chia-LingMcFarland, AndreaSkhinas, Joanna NCox, Thomas RPal, BhupinderHuntington, Nicholas DOrmandy, Christopher JCarroll, JasonVisvader, JaneMolloy, Mark PSwarbrick, Alexander et al. (2021-01)
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  Abundancy of polymorphic CGG repeats in the human genome suggest a broad involvement in neurological disease 

  Annear, Dale J.; Vandeweyer, Geert; Elinck, Ellen; Sanchis-Juan, Alba; French, Courtney E.; Raymond, Lucy; Kooy, R. Frank (Nature Publishing Group UK, 2021-01-28)

  Abstract: Expanded CGG-repeats have been linked to neurodevelopmental and neurodegenerative disorders, including the fragile X syndrome and fragile X-associated tremor/ataxia syndrome (FXTAS). We hypothesized that as of ...
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  Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women 

  Jones, Garan; Trajanoska, Katerina; Santanasto, Adam J.; Stringa, Najada; Kuo, Chia-Ling; Atkins, Janice L.; Lewis, Joshua R.Duong, ThuyVyHong, ShengjunBiggs, Mary L.Luan, Jian’anSarnowski, ChloeLunetta, Kathryn L.Tanaka, ToshikoWojczynski, Mary K.Cvejkus, RyanNethander, MariaGhasemi, SaharYang, JingyunZillikens, M. CarolaWalter, StefanSicinski, KamilKague, ErikaAckert-Bicknell, Cheryl L.Arking, Dan E.Windham, B. GwenBoerwinkle, EricGrove, Megan L.Graff, MisaSpira, DominikDemuth, Iljavan der Velde, Nathaliede Groot, Lisette C. P. G. M.Psaty, Bruce M.Odden, Michelle C.Fohner, Alison E.Langenberg, ClaudiaWareham, Nicholas J.Bandinelli, Stefaniavan Schoor, Natasja M.Huisman, MartijnTan, QihuaZmuda, JosephMellström, DanKarlsson, MagnusBennett, David A.Buchman, Aron S.De Jager, Philip L.Uitterlinden, Andre G.Völker, UweKocher, ThomasTeumer, AlexanderRodriguéz-Mañas, LeocadioGarcía, Francisco J.Carnicero, José A.Herd, PamelaBertram, LarsOhlsson, ClaesMurabito, Joanne M.Melzer, DavidKuchel, George A.Ferrucci, LuigiKarasik, DavidRivadeneira, FernandoKiel, Douglas P.Pilling, Luke C. et al. (Nature Publishing Group UK, 2021-01-28)

  Abstract: Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study meta-analysis of 256,523 Europeans aged 60 years and ...

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