Apollo - University of Cambridge Repository
This repository holds the research output of members of the University of Cambridge. It is delivered and managed by the University Library's Office of Scholarly Communication team.
The ras genes are the most commonly mutated oncogenes in human cancers, with mutations occurring in approximately 20% of human tumours. However, more than 30 years of attempts to target Ras proteins therapeutically have ...
Abundancy of polymorphic CGG repeats in the human genome suggest a broad involvement in neurological disease (Nature Publishing Group UK, 2021-01-28)Abstract: Expanded CGG-repeats have been linked to neurodevelopmental and neurodegenerative disorders, including the fragile X syndrome and fragile X-associated tremor/ataxia syndrome (FXTAS). We hypothesized that as of ...
Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women (Nature Publishing Group UK, 2021-01-28)Abstract: Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study meta-analysis of 256,523 Europeans aged 60 years and ...