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dc.contributor.authorKim, Y
dc.contributor.authorWhite, T
dc.contributor.authorWijndaele, K
dc.contributor.authorSharp, SJ
dc.contributor.authorWareham, NJ
dc.contributor.authorBrage, S
dc.description.abstractBACKGROUND/OBJECTIVES: Fatness and fitness are associated with physical activity (PA) but less is known about the prospective associations of adiposity and muscle strength with PA. This study aimed to determine longitudinal associations of body mass index (BMI), waist circumference (WC) and grip strength (GS) with objectively measured PA. SUBJECTS/METHODS: Data are from the UK Biobank study. At baseline (2006-2010), BMI, WC and GS were objectively measured. At follow-up (2013-2015), a sub-sample of 93 015 participants (52 161 women) wore a tri-axial accelerometer on the dominant wrist for 7 days. Linear regression was performed to investigate longitudinal associations of standardised BMI, WC and GS at baseline with moderate-to-vigorous PA (MVPA) and acceleration after a median 5.7-years follow-up (interquartile range: 4.9-6.5 years). RESULTS: Linear regression revealed strong inverse associations for BMI and WC, and positive associations for GS with follow-up PA; in women, MVPA ranges from lowest to highest quintiles of GS were 42-48 min day(-1) in severely obese (BMI⩾35 kg m(-)(2)), 52-57 min day(-1) in obese (30⩽BMI<35 kg m(-)(2)), 61-65 min day(-1) in overweight (25⩽BMI<30 kg m(-)(2)) and 69-75 min day(-1) in normal weight (18.5⩽BMI<25 kg m(-2)). Follow-up MVPA was also lower in the lowest GS quintile (42-69 min day(-1)) compared with the highest GS quintile (48-75 min day(-1)) across BMI categories in women. The pattern of these associations was generally consistent for men, and in analyses using WC and mean acceleration as exposure and outcome, respectively. CONCLUSIONS: More pronounced obesity and poor strength at baseline independently predict lower activity levels at follow-up. Interventions and policies should aim to improve body composition and muscle strength to promote active living.International Journal of Obesity advance online publication, 6 June 2017; doi:10.1038/ijo.2017.122.
dc.description.sponsorshipThis work was supported by the UK Medical Research Council (MC_UU_12015/3), a PhD studentship from MedImmune (to TW), and an Intermediate Basic Science Research Fellowship of British Heart Foundation (FS/12/58/29709 to KW). No financial disclosures were reported by the authors of this paper. This research has been conducted using the UK Biobank Resource under Application Numbers 262 and 12885.
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.titleAdiposity and grip strength as long-term predictors of objectively measured physical activity in 93 015 adults: the UK Biobank study
prism.publicationNameInternational Journal of Obesity
dc.contributor.orcidKim, Youngwon [0000-0002-7846-7191]
dc.contributor.orcidWhite, Thomas [0000-0001-8456-0803]
dc.contributor.orcidWijndaele, Katrien [0000-0003-2199-7981]
dc.contributor.orcidSharp, Stephen [0000-0003-2375-1440]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idMedical Research Council (MC_UU_12015/3)
pubs.funder-project-idBritish Heart Foundation (None)

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