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dc.contributor.authorThurtle, Daviden
dc.contributor.authorTreece, Grahamen
dc.contributor.authorBarrett, Tristanen
dc.contributor.authorGnanapragasam, Vincenten
dc.date.accessioned2017-09-08T15:39:48Z
dc.date.available2017-09-08T15:39:48Z
dc.date.issued2017-08-30en
dc.identifier.issn1748-717X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/267107
dc.description.abstractImaging of bone metastasis response to therapy is a research priority. Stradwin is a new software-tool, with demonstrated sub-voxel accuracy in assessing cortical bone properties from routine CT. We applied this technology to the context of osseous metastases, with particular focus on disease progression using prostate cancer as a model. 3D–rendered ‘bone-maps’ were produced for 20 men with advanced prostate cancer, including a sub-cohort of 9 who had undergone serial scans. Correlation between baseline interpretation and assessments of progression between modalities was assessed. Bone-maps took significantly less time to interpret than CT bone windows (P < 0.001). Initial bone-mapping, without adjustment, demonstrated sensitivity and specificity for suspicious areas on CT of 70.7% and 73.1% respectively. Evaluating disease over time, concordance between bone-maps and current practice using RECIST outcomes was 100%. This study demonstrates the feasibility and potential use of this free post-processing software in the serial assessment of osseous metastases.
dc.language.isoenen
dc.publisherBioMed Central
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectbone metastasesen
dc.subjectimaging techniquesen
dc.subjectmedical imagingen
dc.subjectprostate canceren
dc.subjectcomputed tomographyen
dc.subject3-D imagingen
dc.titleNovel three-dimensional bone ‘mapping’ software can help assess progression of osseous metastases from routine CTen
dc.typeArticle
prism.number143en
prism.publicationDate2017en
prism.publicationNameRadiation Oncologyen
prism.volume12en
dc.identifier.doi10.17863/CAM.13124
dcterms.dateAccepted2017-08-24en
rioxxterms.versionofrecord10.1186/s13014-017-0880-2en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-08-30en
dc.contributor.orcidThurtle, David [0000-0001-5636-7088]
dc.contributor.orcidTreece, Graham [0000-0003-0047-6845]
dc.contributor.orcidBarrett, Tristan [0000-0002-1180-1474]
dc.contributor.orcidGnanapragasam, Vincent [0000-0003-4722-4207]
dc.identifier.eissn1748-717X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/N014588/1)
cam.issuedOnline2017-08-30en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International