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dc.contributor.authorColes, Charlotteen
dc.contributor.authorYarnold, JRen
dc.date.accessioned2017-09-13T14:42:23Z
dc.date.available2017-09-13T14:42:23Z
dc.date.issued2016-01-16en
dc.identifier.issn0140-6736
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/267200
dc.description.abstractIn The Lancet, Vratislav Strnad and colleagues present 5-year results of a large, international, randomised trial testing standard whole-breast radiotherapy against accelerated partial breast irradiation (APBI) after breast-conserving surgery, in a selected low-risk population of women. The APBI technique entailed a 4–5-day postoperative course of radiotherapy delivered via radioactive sources inserted into breast tissue surrounding the operation site, the so-called tumour bed. The study design tested for non-inferiority with a primary endpoint of local recurrence in 1184 patients recruited from 16 centres, and 5-year local recurrence was less than 2% in both arms. A predefined 3% non-inferiority margin was upheld by a difference in local relapse rates of 0·52% (95% CI −0·72 to 1·75) in favour of whole-breast irradiation. There were no statistical differences in disease-free or overall survival, and adverse effects were similarly mild in both groups.
dc.languageengen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.titleAccelerated partial breast irradiation: the new standard?en
dc.typeArticle
prism.endingPage202
prism.issueIdentifier10015en
prism.publicationDate2016en
prism.publicationNameThe Lanceten
prism.startingPage201
prism.volume387en
dc.identifier.doi10.17863/CAM.13212
dcterms.dateAccepted2015-10-15en
rioxxterms.versionofrecord10.1016/S0140-6736(15)00518-8en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2016-01-16en
dc.contributor.orcidColes, Charlotte [0000-0003-4473-8552]
dc.identifier.eissn1474-547X
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2015-10-19en


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International