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dc.contributor.authorSud, A
dc.contributor.authorThomsen, H
dc.contributor.authorLaw, PJ
dc.contributor.authorFörsti, A
dc.contributor.authorda Silva Filho, MI
dc.contributor.authorHolroyd, A
dc.contributor.authorBroderick, P
dc.contributor.authorOrlando, G
dc.contributor.authorLenive, O
dc.contributor.authorWright, L
dc.contributor.authorCooke, R
dc.contributor.authorEaston, D
dc.contributor.authorPharaoh, P
dc.contributor.authorDunning, A
dc.contributor.authorPeto, J
dc.contributor.authorCanzian, F
dc.contributor.authorEeles, R
dc.contributor.authorKote-Jarai, S
dc.contributor.authorMuir, K
dc.contributor.authorPashayan, N
dc.contributor.authorthe PRACTICAL consortium
dc.contributor.authorHoffman, P
dc.contributor.authorNöthen, MM
dc.contributor.authorJöckel, K-H
dc.contributor.authorvon Strandmann, EP
dc.contributor.authorLightfoot, T
dc.contributor.authorKane, E
dc.contributor.authorRoman, E
dc.contributor.authorLake, A
dc.contributor.authorMontgomery, D
dc.contributor.authorJarrett, RF
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorEngert, A
dc.contributor.authorOrr, N
dc.contributor.authorHemminki, K
dc.contributor.authorHoulston, RS
dc.date.accessioned2017-09-25T09:38:47Z
dc.date.available2017-09-25T09:38:47Z
dc.date.issued2017-12-01
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/267360
dc.description.abstractSeveral susceptibility loci for classical Hodgkin lymphoma (cHL) have been reported, however much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies (GWAS), a new GWAS, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all cHL at 6q22.33 (rs9482849, P=1.52 × 10-8) and for nodular sclerosis HL (NSHL) at 3q28 (rs4459895, P=9.43 × 10-17), 6q23.3 (rs6928977, P=4.62 × 10-55 11), 10p14 (rs3781093, P=9.49 × 10-13), 13q34 (rs112998813, P=4.58 × 10-8) and 16p13.13 (rs34972832, P=2.12 × 10-8). Additionally, independent loci within the HLA region are observed for NSHL (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity HL (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.
dc.description.sponsorshipIn the United Kingdom, Bloodwise (LLR; 10021) provided principal funding for the study. Support from Cancer Research UK (C1298/A8362 supported by the Bobby Moore Fund) and the Lymphoma Research Trust is also acknowledged. A.S. is supported by a clinical fellowship from Cancer Research UK. For the UK-GWAS, sample and data acquisition were supported by Breast Cancer Now, the European Union and the Lymphoma Research Trust. The UK-GWAS made use of control genotyping data generated by the WTCCC. For further information, please visit the publishr's website.
dc.languageeng
dc.language.isoen
dc.publisherSpringer Nature
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleGenome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility
dc.typeArticle
prism.number1892 (2017)
prism.publicationDate2017
prism.publicationNameNature Communications
prism.volume8
dc.identifier.doi10.17863/CAM.13345
dcterms.dateAccepted2017-06-20
rioxxterms.versionofrecord10.1038/s41467-017-00320-1
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2017-12-01
dc.contributor.orcidEaston, Douglas [0000-0003-2444-3247]
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.contributor.orcidDunning, Alison [0000-0001-6651-7166]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idNational Cancer Institute (U19CA148537)
pubs.funder-project-idMedical Research Council (G0401527)
pubs.funder-project-idMedical Research Council (G1000143)
pubs.funder-project-idMedical Research Council (MR/N003284/1)
pubs.funder-project-idCancer Research UK (A16563)
pubs.funder-project-idCancer Research UK (A10118)
pubs.funder-project-idEuropean Commission (223175)
cam.issuedOnline2017-12-01
cam.orpheus.successThu Jan 30 12:59:43 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International