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dc.contributor.authorFernandez Egea, E
dc.contributor.authorworbe, yulia
dc.contributor.authorbernardo, Miguel
dc.contributor.authorRobbins, Trevor W
dc.date.accessioned2018-02-05T17:29:35Z
dc.date.available2018-02-05T17:29:35Z
dc.date.issued2018-12
dc.identifier.issn0033-2917
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/271698
dc.description.abstractObjective: Obsessive-compulsive disorder (OCD) is common in clozapine-treated patients alt-hough the actual prevalence, phenomenology and risk factors remain unclear. The aim of the pre-sent study was to address the three aforementioned questions. Method: The electronic records of a large cohort of clozapine-medicated schizophrenia patients routinely screened for OCD were used. The Obsessive Compulsive Inventory Revised version (OCI-R) was available from 118 cases and a 21 points cut-off threshold for OCD was defined. Results: OCD prevalence was 47%, higher in patients on poly-pharmacy than on monotherapy (64% vs 31%; p=.001). Two OCI-R factors had significantly higher scores and distinct risk factors: checking behaviour (mean=5.1; SD=3.6) correlated with length of clozapine treatment (r=.21; p=.026), and obsessing factor (mean=4.8; SD=3.6) correlated with psychosis severity (r=.59; p=.001). These factors along with total OCI-R, did not correlate with either clozapine dose or plas-ma levels, after correcting for psychosis severity. Conclusion: Screening for OCD in clozapine patients, and probably in those treated with structur-ally similar drugs with potent antiserotoninergic properties, should be widely adopted by clinicians. Further research is needed to understand the pathophysiology underlying repetitive behavior onset in clozapine-treated patients.
dc.description.sponsorshipDr. Fernandez-Egea was supported by 2009 Young investigator award and intramural funding from CPFT/NIHR-CRN supported setting the database. Prof. Bernardo is funded by the Spanish Ministry of Science and Education, the Spanish Ministry of Economy and Competiveness, Centro de Inves-tigación Biomédica en Red de Salud Mental (CIBERSAM), from the Government of Catalonia, Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement (2014SGR441), from the Foundation European Group for Research In Schizophrenia (EGRIS) , and from the 7th Framework Program of the European Union. Dr. Y Worbe is supported by Association Française du syndrome de Gilles de la Tourette, Founda-tion de recherche Medicale and Dystonia Foundation for Medical Research (USA). Prof. TW Robbins' research is funded by a Wellcome Senior Investigator Award (104631/Z/14/Z). Work was completed at the Behavioural and Clinical Neuroscience Institute, which was supported by a joint award from the Medical Research Council and Wellcome Trust (G00001354).
dc.language.isoen
dc.publisherCambridge University Press
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectantipsychotics
dc.subjecthabit formation
dc.subjectclozapine
dc.subjectschizophrenia
dc.subjectobsessive compulsive disorder
dc.titleDistinct risk factors for obsessive and compulsive symptoms in chronic schizophrenia
dc.typeArticle
prism.publicationNamePsychological Medicine
dc.identifier.doi10.17863/CAM.18683
dcterms.dateAccepted2018-01-11
rioxxterms.versionofrecord10.1017/S003329171800017X
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2018-01-11
dc.contributor.orcidFernandez Egea, Emilio [0000-0003-4128-8955]
dc.contributor.orcidRobbins, Trevor [0000-0003-0642-5977]
dc.identifier.eissn1469-8978
dc.publisher.urlhttps://www.cambridge.org/core/journals/psychological-medicine/article/distinct-risk-factors-for-obsessive-and-compulsive-symptoms-in-chronic-schizophrenia/D626F1B0913344E7B35314F58CC3C435
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (G1000183)
pubs.funder-project-idWellcome Trust (104631/Z/14/Z)
pubs.funder-project-idMedical Research Council (G0001354)
cam.issuedOnline2018-02-19
dc.identifier.urlhttps://www.cambridge.org/core/journals/psychological-medicine/article/distinct-risk-factors-for-obsessive-and-compulsive-symptoms-in-chronic-schizophrenia/D626F1B0913344E7B35314F58CC3C435
cam.orpheus.successThu Jan 30 13:00:32 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2100-01-01


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