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dc.contributor.authorMacKay, Jamesen
dc.contributor.authorLow, SBLen
dc.contributor.authorSmith, TOen
dc.contributor.authorToms, APen
dc.contributor.authorMcCaskie, Andrewen
dc.contributor.authorGilbert, Fionaen
dc.date.accessioned2018-02-06T13:30:09Z
dc.date.available2018-02-06T13:30:09Z
dc.date.issued2018-09en
dc.identifier.issn1063-4584
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/271716
dc.description.abstractObjective To assess reliability and discriminative validity of cartilage compositional magnetic resonance imaging (MRI) in knee osteoarthritis (OA). Design The study was carried out per PRISMA recommendations. We searched MEDLINE and EMBASE (1974 - present) for eligible studies. We performed qualitative synthesis of reliability data. Where data from at least 2 discrimination studies were available, we estimated pooled standardized mean difference (SMD) between subjects with and without OA. Discrimination analyses compared controls and subjects with mild OA (Kellgren-Lawrence (KL) grade 1-2), severe OA (KL grade 3-4) and OA not otherwise specified (NOS) where not possible to stratify. We assessed quality of the evidence using QAREL and QUADAS-2 tools. Results Fifty-eight studies were included in the reliability analysis and 25 studies were included in the discrimination analysis, with data from a total of 1,989 knees. Intra-observer, inter-observer and test-retest reliability of compositional techniques were excellent with most intraclass correlation coefficients > 0.8 and coefficients of variation < 10%. T1rho and T2 relaxometry were significant discriminators between subjects with mild OA and controls, and between subjects with OA (NOS) and controls (p < 0.001). T1rho showed best discrimination for mild OA (SMD [95% CI] = 0.73 [0.40 to 1.06], p < 0.001) and OA (NOS) (0.60 [0.41 to 0.80], p < 0.001). Quality of evidence was moderate for both parts of the review. Conclusions Cartilage compositional MRI techniques are reliable and, in the case of T1rho and T2 relaxometry, can discriminate between subjects with OA and controls.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherElsevier
dc.subjectCartilage, Articularen
dc.subjectHumansen
dc.subjectOsteoarthritis, Kneeen
dc.subjectMagnetic Resonance Imagingen
dc.subjectSeverity of Illness Indexen
dc.subjectSensitivity and Specificityen
dc.subjectCase-Control Studiesen
dc.subjectReproducibility of Resultsen
dc.subjectReference Valuesen
dc.subjectAgeden
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.titleSystematic review and meta-analysis of the reliability and discriminative validity of cartilage compositional MRI in knee osteoarthritis.en
dc.typeArticle
prism.endingPage1152
prism.issueIdentifier9en
prism.publicationDate2018en
prism.publicationNameOsteoarthritis and cartilageen
prism.startingPage1140
prism.volume26en
dc.identifier.doi10.17863/CAM.18709
dcterms.dateAccepted2017-11-14en
rioxxterms.versionofrecord10.1016/j.joca.2017.11.018en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2018-09en
dc.contributor.orcidMacKay, James [0000-0001-7558-3800]
dc.contributor.orcidSmith, TO [0000-0003-1673-2954]
dc.contributor.orcidMcCaskie, Andrew [0000-0001-6476-0832]
dc.contributor.orcidGilbert, Fiona [0000-0002-0124-9962]
dc.identifier.eissn1522-9653
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idAddenbrooke's Charitable Trust (ACT) (24/15 A)
pubs.funder-project-idMRC (MC_PC_12009)
rioxxterms.freetoread.startdate2019-03-14


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