Show simple item record

dc.contributor.authorOrellana-Tavra, Cen
dc.contributor.authorHaddad, Salameen
dc.contributor.authorMarshall, Ren
dc.contributor.authorAbanades Lazaro, Ien
dc.contributor.authorBoix, Gen
dc.contributor.authorImaz, Ien
dc.contributor.authorMaspoch, Den
dc.contributor.authorForgan, Ren
dc.contributor.authorFairen Jimenez, Daviden
dc.date.accessioned2018-04-12T17:37:55Z
dc.date.available2018-04-12T17:37:55Z
dc.identifier.issn1944-8244
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/274821
dc.description.abstractA critical bottleneck for the use of metal-organic frameworks (MOFs) as drug delivery systems has been allowing them to reach their intracellular targets without being degraded in the acidic environment of the lysosomes. Cells take up particles by endocytosis through multiple biochemical pathways, and the fate of these particles depends on these routes of entry. Here, we show the effect of functional group incorporation into a series of Zr-based MOFs on their endocytosis mechanisms, allowing us to design an effi-cient drug delivery system. In particular, naphthalene-2,6-dicarboxylic acid and 4,4'-biphenyldicarboxylic acid ligands promote entry through the caveolin-pathway, allowing the particles to avoid lysosomal degradation and be delivered into the cytosol, en-hancing their therapeutic activity when loaded with drugs.
dc.description.sponsorshipC.A.O. thanks Becas Chile and the Cambridge Trust for funding. S.H. thanks the Cambridge Trust for funding. R.S.F. and D.F.-J. thank the Royal Society for the receipt of University Research Fellowships. D.F.-J. thanks financial support from ERC-2016-COG 726380. R.S.F., R.J.M., and I.A.L. thank the University of Glasgow and the EPSRC (EP/L004461/1) for funding. G.B., I.I., and D.M. acknowledge the financial support from 2014-SGR-80, MAT2015-65354-C2-1-R and EU FP7 ERC-Co 615954. ICN2 received support from the Spanish MINECO through the Severo Ochoa Centers of Excellence Program, under Grant No. SEV-2013-0295.
dc.publisherAmerican Chemical Society
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectmetal−organic frameworksen
dc.subjectmetabolic pathwaysen
dc.subjectdrug deliveryen
dc.subjectendocytosisen
dc.titleTuning the Endocytosis Mechanism of Zr-Based Metal–Organic Frameworks through Linker Functionalizationen
dc.typeArticle
prism.endingPage35525
prism.issueIdentifier41en
prism.publicationNameACS Applied Materials & Interfacesen
prism.startingPage35516
prism.volume9en
dc.identifier.doi10.17863/CAM.21970
dcterms.dateAccepted2017-09-19en
rioxxterms.versionofrecord10.1021/acsami.7b07342en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-09-19en
dc.contributor.orcidFairen Jimenez, David [0000-0002-5013-1194]
dc.identifier.eissn1944-8252
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idRoyal Society (uf110211)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) ERC (726380)
cam.issuedOnline2017-09-19en


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International