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dc.contributor.authorMc Ardle, Ríonaen
dc.contributor.authorMorris, Rosieen
dc.contributor.authorHickey, Aodhánen
dc.contributor.authorDel Din, Silviaen
dc.contributor.authorKoychev, Ivanen
dc.contributor.authorGunn, Roger Nen
dc.contributor.authorLawson, Jenniferen
dc.contributor.authorZamboni, Giovannaen
dc.contributor.authorRidha, Basilen
dc.contributor.authorSahakian, Barbaraen
dc.contributor.authorRowe, Jamesen
dc.contributor.authorThomas, Alanen
dc.contributor.authorZetterberg, Henriken
dc.contributor.authorMacKay, Clareen
dc.contributor.authorLovestone, Simonen
dc.contributor.authorRochesteron, Lynnen
dc.contributor.authorDeep and Frequent Phenotyping study team (,en
dc.date.accessioned2018-04-23T09:10:20Z
dc.date.available2018-04-23T09:10:20Z
dc.date.issued2018-01en
dc.identifier.issn1387-2877
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/275101
dc.description.abstractGait is emerging as a potential diagnostic tool for cognitive decline. . The ‘Deep and Frequent Phenotyping for Experimental Medicine in Dementia Study’ (D&FP) is a multicentre feasibility study embedded in the United Kingdom Dementia Platform designed to determine participant acceptability and feasibility of extensive and repeated phenotyping to determine the optimal combination of biomarkers to detect disease progression and identify early risk of Alzheimer’s Disease. Gait is included as a clinical biomarker. The tools to quantify gait in the clinic and home, and suitability for multi-centre application have not been examined. Six centres from the National Institute for Health Research Translational Research Collaboration in Dementia initiative recruited 20 individuals with early onset Alzheimer’s disease. Participants wore a single wearable (tri-axial accelerometer) and completed both clinic-based and free-living gait assessment. A series of macro (behavioural) and micro (spatiotemporal) characteristics were derived from the resultant data using previously validated algorithms. Results indicate good participant acceptability, and potential for use of body-worn sensors in both the clinic and the home. Recommendations for future studies have been provided. Gait has been demonstrated to be a feasible and suitable measure, and future research should examine its suitability as a biomarker in Alzheimer’s Disease.
dc.format.mediumPrinten
dc.languageengen
dc.publisherIOS Press
dc.subjectDeep and Frequent Phenotyping study team (en
dc.subjectHumansen
dc.subjectAlzheimer Diseaseen
dc.subjectGait Disorders, Neurologicen
dc.subjectFeasibility Studiesen
dc.subjectPilot Projectsen
dc.subjectCognition Disordersen
dc.subjectPsychiatric Status Rating Scalesen
dc.subjectNeuropsychological Testsen
dc.subjectTime Factorsen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectMiddle Ageden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectAccelerometryen
dc.subjectUnited Kingdomen
dc.subjectWearable Electronic Devicesen
dc.titleGait in Mild Alzheimer's Disease: Feasibility of Multi-Center Measurement in the Clinic and Home with Body-Worn Sensors: A Pilot Study.en
dc.typeArticle
prism.endingPage341
prism.issueIdentifier1en
prism.publicationDate2018en
prism.publicationNameJournal of Alzheimer's disease : JADen
prism.startingPage331
prism.volume63en
dc.identifier.doi10.17863/CAM.22280
dc.identifier.doi10.17863/CAM.22280
dcterms.dateAccepted2018-02-05en
rioxxterms.versionofrecord10.3233/jad-171116en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-01en
dc.contributor.orcidMc Ardle, Ríona [0000-0001-7959-3563]
dc.contributor.orcidDel Din, Silvia [0000-0003-1154-4751]
dc.contributor.orcidKoychev, Ivan [0000-0001-6813-8493]
dc.contributor.orcidGunn, Roger N [0000-0003-1181-5769]
dc.contributor.orcidLawson, Jennifer [0000-0003-2637-7546]
dc.contributor.orcidSahakian, Barbara [0000-0001-7352-1745]
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.contributor.orcidMacKay, Clare [0000-0001-6111-8318]
dc.contributor.orcidLovestone, Simon [0000-0003-0473-4565]
dc.identifier.eissn1875-8908
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (103838/Z/14/Z)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idMedical Research Council (MC_U105597119)


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