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dc.contributor.authorSteventon, Benjaminen
dc.contributor.authorMayor, Robertoen
dc.contributor.authorStreit, Andreaen
dc.date.accessioned2018-05-29T14:08:16Z
dc.date.available2018-05-29T14:08:16Z
dc.date.issued2016-11-15en
dc.identifier.issn2046-6390
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/276269
dc.description.abstractCranial placodes contribute to sensory structures including the inner ear, the lens and olfactory epithelium and the neurons of the cranial sensory ganglia. At neurula stages, placode precursors are interspersed in the ectoderm surrounding the anterior neural plate before segregating into distinct placodes by as yet unknown mechanisms. Here, we perform live imaging to follow placode progenitors as they aggregate to form the lens and otic placodes. We find that while placode progenitors move with the same speed as their non-placodal neighbours, they exhibit increased persistence and directionality and these properties are required to assemble morphological placodes. Furthermore, we demonstrate that these factors are components of the transcriptional networks that coordinate placode cell behaviour including their directional movements. Together with previous work, our results support a dual role for Otx and Gbx transcription factors in both the early patterning of the neural plate border and the later segregation of its derivatives into distinct placodes.
dc.format.mediumElectronicen
dc.languageengen
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleDirectional cell movements downstream of Gbx2 and Otx2 control the assembly of sensory placodes.en
dc.typeArticle
prism.endingPage1624
prism.issueIdentifier11en
prism.publicationDate2016en
prism.publicationNameBiology openen
prism.startingPage1620
prism.volume5en
dc.identifier.doi10.17863/CAM.23558
dcterms.dateAccepted2016-09-09en
rioxxterms.versionofrecord10.1242/bio.020966en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-11-15en
dc.contributor.orcidSteventon, Benjamin [0000-0001-7838-839X]
dc.contributor.orcidStreit, Andrea [0000-0001-7664-7917]
dc.identifier.eissn2046-6390
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (109408/Z/15/Z)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International