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dc.contributor.authorBraicu, Elena Ioanaen
dc.contributor.authorDarb-Esfahani, Silviaen
dc.contributor.authorSchmitt, Wolfgang Den
dc.contributor.authorKoistinen, Kaisa Men
dc.contributor.authorHeiskanen, Lauraen
dc.contributor.authorPöhö, Päivien
dc.contributor.authorBudczies, Janen
dc.contributor.authorKuhberg, Marcen
dc.contributor.authorDietel, Manfreden
dc.contributor.authorFrezza, Christianen
dc.contributor.authorDenkert, Carstenen
dc.contributor.authorSehouli, Jaliden
dc.contributor.authorHilvo, Mikaen
dc.date.accessioned2018-05-31T14:23:37Z
dc.date.available2018-05-31T14:23:37Z
dc.date.issued2017-11en
dc.identifier.issn1949-2553
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/276412
dc.description.abstractOvarian cancer is a very severe type of disease with poor prognosis. Treatment of ovarian cancer is challenging because of the lack of tests for early detection and effective therapeutic targets. Thus, new biomarkers are needed for both diagnostics and better understanding of the cellular processes of the disease. Small molecules, consisting of metabolites or lipids, have shown emerging potential for ovarian cancer diagnostics. Here we performed comprehensive lipidomic profiling of serum and tumor tissue samples from high-grade serous ovarian cancer patients to find lipids that were altered due to cancer and also associated with progression of the disease. Ovarian cancer patients exhibited an overall reduction of most lipid classes in their serum as compared to a control group. Despite the overall reduction, there were also specific lipids showing elevation, and especially alterations in ceramide and triacylglycerol lipid species were dependent on their fatty acyl side chain composition. Several lipids showed progressive alterations in patients with more advanced disease and poorer overall survival, and outperformed CA-125 as prognostic markers. The abundance of many serum lipids correlated with their abundance in tumor tissue samples. Furthermore, we found a negative correlation of serum lipids with 3-hydroxybutyric acid, suggesting an association between decreased lipid levels and fatty acid oxidation. In conclusion, here we present a comprehensive analysis of lipid metabolism alterations in ovarian cancer patients, with clinical implications.
dc.format.mediumElectronic-eCollectionen
dc.languageengen
dc.publisherImpact Journals
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleHigh-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism.en
dc.typeArticle
prism.endingPage102922
prism.issueIdentifier61en
prism.publicationDate2017en
prism.publicationNameOncotargeten
prism.startingPage102912
prism.volume8en
dc.identifier.doi10.17863/CAM.23715
dcterms.dateAccepted2017-10-11en
rioxxterms.versionofrecord10.18632/oncotarget.22076en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-11en
dc.contributor.orcidSchmitt, Wolfgang D [0000-0002-7870-138X]
dc.contributor.orcidPöhö, Päivi [0000-0001-9963-4027]
dc.contributor.orcidFrezza, Christian [0000-0002-3293-7397]
dc.identifier.eissn1949-2553
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12022/1_do not transfer?)
pubs.funder-project-idMedical Research Council (MC_UU_12022/6)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International