Show simple item record

dc.contributor.authorSt Johnston, Danielen
dc.date.accessioned2018-06-04T10:04:30Z
dc.date.available2018-06-04T10:04:30Z
dc.date.issued2018-04-01en
dc.identifier.issn0955-0674
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/276498
dc.description.abstractAll cells in vivo have a primary axis of polarity that controls many aspects of their behaviour, such as the direction of protein secretion and signalling, the orientation of cell division and directed cell movement and morphogenesis. Cell polarise in response to extracellular cues or intracellular landmarks that initiate a signal transduction process that establishes complementary cortical domains of conserved polarity factors. These cortical domains then transmit this polarity to the rest of the cell by regulating the organisation of the cytoskeleton and membrane trafficking systems. Here I review work over the past couple of years that has elucidated many key features of how polarity is established and transduced in different systems, but has also revealed unexpected variations in polarity mechanisms depending on context.
dc.description.sponsorshipI am supported by Wellcome Principal Research Fellowship 080007/B/06/Z.
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleEstablishing and transducing cell polarity: common themes and variationsen
dc.typeArticle
prism.endingPage41
prism.publicationDate2018en
prism.publicationNameCurrent Opinion in Cell biologyen
prism.startingPage33
prism.volume51en
dc.identifier.doi10.17863/CAM.23797
dcterms.dateAccepted2017-10-18en
rioxxterms.versionofrecord10.1016/j.ceb.2017.10.007en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2018-04-01en
dc.contributor.orcidSt Johnston, Daniel [0000-0001-5582-3301]
dc.identifier.eissn1879-0410
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (207496/Z/17/Z)
pubs.funder-project-idWellcome Trust (080007/B/06/Z)
cam.issuedOnline2017-11-15en
rioxxterms.freetoread.startdate2018-11-15


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International