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dc.contributor.authorDudas, Gytisen
dc.contributor.authorCarvalho, Luiz Maxen
dc.contributor.authorBedford, Trevoren
dc.contributor.authorTatem, Andrew Jen
dc.contributor.authorBaele, Guyen
dc.contributor.authorFaria, Nuno Ren
dc.contributor.authorPark, Daniel Jen
dc.contributor.authorLadner, Jason Ten
dc.contributor.authorArias, Armandoen
dc.contributor.authorAsogun, Dannyen
dc.contributor.authorBielejec, Filipen
dc.contributor.authorCaddy, Sarahen
dc.contributor.authorCotten, Matthewen
dc.contributor.authorD'Ambrozio, Jonathanen
dc.contributor.authorDellicour, Simonen
dc.contributor.authorDi Caro, Antoninoen
dc.contributor.authorDiclaro, Joseph Wen
dc.contributor.authorDuraffour, Sophieen
dc.contributor.authorElmore, Michael Jen
dc.contributor.authorFakoli, Lawrence Sen
dc.contributor.authorFaye, Ousmaneen
dc.contributor.authorGilbert, Merle Len
dc.contributor.authorGevao, Sahr Men
dc.contributor.authorGire, Stephenen
dc.contributor.authorGladden-Young, Adrianneen
dc.contributor.authorGnirke, Andreasen
dc.contributor.authorGoba, Augustineen
dc.contributor.authorGrant, Donald Sen
dc.contributor.authorHaagmans, Bart Len
dc.contributor.authorHiscox, Julian Aen
dc.contributor.authorJah, Umaruen
dc.contributor.authorKugelman, Jeffrey Ren
dc.contributor.authorLiu, Dien
dc.contributor.authorLu, Jiaen
dc.contributor.authorMalboeuf, Christine Men
dc.contributor.authorMate, Suzanneen
dc.contributor.authorMatthews, David Aen
dc.contributor.authorMatranga, Christian Ben
dc.contributor.authorMeredith, Lukeen
dc.contributor.authorQu, Jamesen
dc.contributor.authorQuick, Joshuaen
dc.contributor.authorPas, Suzan Den
dc.contributor.authorPhan, My VTen
dc.contributor.authorPollakis, Georgiosen
dc.contributor.authorReusken, Chantal Ben
dc.contributor.authorSanchez-Lockhart, Marianoen
dc.contributor.authorSchaffner, Stephen Fen
dc.contributor.authorSchieffelin, John Sen
dc.contributor.authorSealfon, Rachel Sen
dc.contributor.authorSimon-Loriere, Etienneen
dc.contributor.authorSmits, Saskia Len
dc.contributor.authorStoecker, Kilianen
dc.contributor.authorThorne, Lucyen
dc.contributor.authorTobin, Ekaete Aliceen
dc.contributor.authorVandi, Mohamed Aen
dc.contributor.authorWatson, Simon Jen
dc.contributor.authorWest, Kendraen
dc.contributor.authorWhitmer, Shannonen
dc.contributor.authorWiley, Michael Ren
dc.contributor.authorWinnicki, Sarah Men
dc.contributor.authorWohl, Shirleeen
dc.contributor.authorWölfel, Romanen
dc.contributor.authorYozwiak, Nathan Len
dc.contributor.authorAndersen, Kristian Gen
dc.contributor.authorBlyden, Sylvia Oen
dc.contributor.authorBolay, Fatormaen
dc.contributor.authorCarroll, Miles Wen
dc.contributor.authorDahn, Berniceen
dc.contributor.authorDiallo, Boubacaren
dc.contributor.authorFormenty, Pierreen
dc.contributor.authorFraser, Christopheen
dc.contributor.authorGao, George Fen
dc.contributor.authorGarry, Robert Fen
dc.contributor.authorGoodfellow, Ianen
dc.contributor.authorGünther, Stephanen
dc.contributor.authorHappi, Christian Ten
dc.contributor.authorHolmes, Edward Cen
dc.contributor.authorKargbo, Brimaen
dc.contributor.authorKeïta, Sakobaen
dc.contributor.authorKellam, Paulen
dc.contributor.authorKoopmans, Marion PGen
dc.contributor.authorKuhn, Jens Hen
dc.contributor.authorLoman, Nicholas Jen
dc.contributor.authorMagassouba, N'Falyen
dc.contributor.authorNaidoo, Dhamarien
dc.contributor.authorNichol, Stuart Ten
dc.contributor.authorNyenswah, Tolberten
dc.contributor.authorPalacios, Gustavoen
dc.contributor.authorPybus, Oliver Gen
dc.contributor.authorSabeti, Pardis Cen
dc.contributor.authorSall, Amadouen
dc.contributor.authorStröher, Uteen
dc.contributor.authorWurie, Isattaen
dc.contributor.authorSuchard, Marc Aen
dc.contributor.authorLemey, Philippeen
dc.contributor.authorRambaut, Andrewen
dc.date.accessioned2018-06-12T10:43:43Z
dc.date.available2018-06-12T10:43:43Z
dc.date.issued2017-04-20en
dc.identifier.issn0028-0836
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/276901
dc.description.abstractThe 2013-2016 West African epidemic caused by the Ebola virus was of unprecedented magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of Ebola virus throughout the region by analysing 1,610 Ebola virus genomes, which represent over 5% of the known cases. We test the association of geography, climate and demography with viral movement among administrative regions, inferring a classic 'gravity' model, with intense dispersal between larger and closer populations. Despite attenuation of international dispersal after border closures, cross-border transmission had already sown the seeds for an international epidemic, rendering these measures ineffective at curbing the epidemic. We address why the epidemic did not spread into neighbouring countries, showing that these countries were susceptible to substantial outbreaks but at lower risk of introductions. Finally, we reveal that this large epidemic was a heterogeneous and spatially dissociated collection of transmission clusters of varying size, duration and connectivity. These insights will help to inform interventions in future epidemics.
dc.languageengen
dc.titleVirus genomes reveal factors that spread and sustained the Ebola epidemic.en
dc.typeArticle
prism.issueIdentifier7650en
prism.publicationDate2017en
prism.publicationNameNatureen
prism.volume544en
dc.identifier.doi10.17863/CAM.24183
dcterms.dateAccepted2017-03-02en
rioxxterms.versionofrecord10.1038/nature22040en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-04-20en
dc.contributor.orcidCaddy, Sarah [0000-0002-9790-7420]
dc.contributor.orcidLu, Jia [0000-0003-3995-324X]
dc.contributor.orcidMeredith, Luke [0000-0002-3802-8290]
dc.contributor.orcidGoodfellow, Ian [0000-0002-9483-510X]
dc.identifier.eissn1476-4687
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (097997/Z/11/Z)
pubs.funder-project-idBBSRC (BB/N001176/1)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Societal Challenges (643476)
cam.issuedOnline2017-04-12en


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