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dc.contributor.authorNasralla, David
dc.contributor.authorCoussios, Constantin C
dc.contributor.authorMergental, Hynek
dc.contributor.authorAkhtar, M Zeeshan
dc.contributor.authorButler, Andrew
dc.contributor.authorCeresa, Carlo DL
dc.contributor.authorChiocchia, Virginia
dc.contributor.authorDutton, Susan J
dc.contributor.authorGarcía-Valdecasas, Juan Carlos
dc.contributor.authorHeaton, Nigel
dc.contributor.authorImber, Charles
dc.contributor.authorJassem, Wayel
dc.contributor.authorJochmans, Ina
dc.contributor.authorKarani, John
dc.contributor.authorKnight, Simon R
dc.contributor.authorKocabayoglu, Peri
dc.contributor.authorMalagò, Massimo
dc.contributor.authorMirza, Darius
dc.contributor.authorMorris, Peter J
dc.contributor.authorPallan, Arvind
dc.contributor.authorPaul, Andreas
dc.contributor.authorPavel, Mihai
dc.contributor.authorPerera, M Thamara PR
dc.contributor.authorPirenne, Jacques
dc.contributor.authorRavikumar, Reena
dc.contributor.authorRussell, Leslie
dc.contributor.authorUpponi, Sara
dc.contributor.authorWatson, Christopher
dc.contributor.authorWeissenbacher, Annemarie
dc.contributor.authorPloeg, Rutger J
dc.contributor.authorFriend, Peter J
dc.contributor.authorConsortium for Organ Preservation in Europe
dc.date.accessioned2018-06-12T10:51:20Z
dc.date.available2018-06-12T10:51:20Z
dc.date.issued2018-05
dc.identifier.issn0028-0836
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/276902
dc.description.abstractLiver transplantation is a highly successful treatment, but is severely limited by the shortage in donor organs. However, many potential donor organs cannot be used; this is because sub-optimal livers do not tolerate conventional cold storage and there is no reliable way to assess organ viability preoperatively. Normothermic machine perfusion maintains the liver in a physiological state, avoids cooling and allows recovery and functional testing. Here we show that, in a randomized trial with 220 liver transplantations, compared to conventional static cold storage, normothermic preservation is associated with a 50% lower level of graft injury, measured by hepatocellular enzyme release, despite a 50% lower rate of organ discard and a 54% longer mean preservation time. There was no significant difference in bile duct complications, graft survival or survival of the patient. If translated to clinical practice, these results would have a major impact on liver transplant outcomes and waiting list mortality.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.subjectConsortium for Organ Preservation in Europe
dc.subjectBile Ducts
dc.subjectLiver
dc.subjectHumans
dc.subjectOrgan Preservation
dc.subjectTissue and Organ Harvesting
dc.subjectTreatment Outcome
dc.subjectLength of Stay
dc.subjectLiver Transplantation
dc.subjectSurvival Analysis
dc.subjectPerfusion
dc.subjectTemperature
dc.subjectGraft Survival
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectTissue Donors
dc.subjectWaiting Lists
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.subjectAllografts
dc.titleA randomized trial of normothermic preservation in liver transplantation.
dc.typeArticle
prism.endingPage56
prism.issueIdentifier7703
prism.publicationDate2018
prism.publicationNameNature
prism.startingPage50
prism.volume557
dc.identifier.doi10.17863/CAM.24184
dcterms.dateAccepted2018-03-08
rioxxterms.versionofrecord10.1038/s41586-018-0047-9
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-05
dc.contributor.orcidWatson, Christopher [0000-0002-0590-4901]
dc.identifier.eissn1476-4687
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-04-18
rioxxterms.freetoread.startdate2018-10-18


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