A randomized trial of normothermic preservation in liver transplantation.
dc.contributor.author | Nasralla, David | |
dc.contributor.author | Coussios, Constantin C | |
dc.contributor.author | Mergental, Hynek | |
dc.contributor.author | Akhtar, M Zeeshan | |
dc.contributor.author | Butler, Andrew J | |
dc.contributor.author | Ceresa, Carlo DL | |
dc.contributor.author | Chiocchia, Virginia | |
dc.contributor.author | Dutton, Susan J | |
dc.contributor.author | García-Valdecasas, Juan Carlos | |
dc.contributor.author | Heaton, Nigel | |
dc.contributor.author | Imber, Charles | |
dc.contributor.author | Jassem, Wayel | |
dc.contributor.author | Jochmans, Ina | |
dc.contributor.author | Karani, John | |
dc.contributor.author | Knight, Simon R | |
dc.contributor.author | Kocabayoglu, Peri | |
dc.contributor.author | Malagò, Massimo | |
dc.contributor.author | Mirza, Darius | |
dc.contributor.author | Morris, Peter J | |
dc.contributor.author | Pallan, Arvind | |
dc.contributor.author | Paul, Andreas | |
dc.contributor.author | Pavel, Mihai | |
dc.contributor.author | Perera, M Thamara PR | |
dc.contributor.author | Pirenne, Jacques | |
dc.contributor.author | Ravikumar, Reena | |
dc.contributor.author | Russell, Leslie | |
dc.contributor.author | Upponi, Sara | |
dc.contributor.author | Watson, Chris JE | |
dc.contributor.author | Weissenbacher, Annemarie | |
dc.contributor.author | Ploeg, Rutger J | |
dc.contributor.author | Friend, Peter J | |
dc.contributor.author | Consortium for Organ Preservation in Europe | |
dc.date.accessioned | 2018-06-12T10:51:20Z | |
dc.date.available | 2018-06-12T10:51:20Z | |
dc.date.issued | 2018-05 | |
dc.identifier.issn | 0028-0836 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/276902 | |
dc.description.abstract | Liver transplantation is a highly successful treatment, but is severely limited by the shortage in donor organs. However, many potential donor organs cannot be used; this is because sub-optimal livers do not tolerate conventional cold storage and there is no reliable way to assess organ viability preoperatively. Normothermic machine perfusion maintains the liver in a physiological state, avoids cooling and allows recovery and functional testing. Here we show that, in a randomized trial with 220 liver transplantations, compared to conventional static cold storage, normothermic preservation is associated with a 50% lower level of graft injury, measured by hepatocellular enzyme release, despite a 50% lower rate of organ discard and a 54% longer mean preservation time. There was no significant difference in bile duct complications, graft survival or survival of the patient. If translated to clinical practice, these results would have a major impact on liver transplant outcomes and waiting list mortality. | |
dc.format.medium | Print-Electronic | |
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.subject | Consortium for Organ Preservation in Europe | |
dc.subject | Bile Ducts | |
dc.subject | Liver | |
dc.subject | Humans | |
dc.subject | Organ Preservation | |
dc.subject | Tissue and Organ Harvesting | |
dc.subject | Treatment Outcome | |
dc.subject | Length of Stay | |
dc.subject | Liver Transplantation | |
dc.subject | Survival Analysis | |
dc.subject | Perfusion | |
dc.subject | Temperature | |
dc.subject | Graft Survival | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Middle Aged | |
dc.subject | Tissue Donors | |
dc.subject | Waiting Lists | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Young Adult | |
dc.subject | Allografts | |
dc.title | A randomized trial of normothermic preservation in liver transplantation. | |
dc.type | Article | |
prism.endingPage | 56 | |
prism.issueIdentifier | 7703 | |
prism.publicationDate | 2018 | |
prism.publicationName | Nature | |
prism.startingPage | 50 | |
prism.volume | 557 | |
dc.identifier.doi | 10.17863/CAM.24184 | |
dcterms.dateAccepted | 2018-03-08 | |
rioxxterms.versionofrecord | 10.1038/s41586-018-0047-9 | |
rioxxterms.version | AM | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2018-05 | |
dc.contributor.orcid | Watson, Christopher [0000-0002-0590-4901] | |
dc.identifier.eissn | 1476-4687 | |
rioxxterms.type | Journal Article/Review | |
cam.issuedOnline | 2018-04-18 | |
rioxxterms.freetoread.startdate | 2018-10-18 |