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dc.contributor.authorHeller, Gabriella T
dc.contributor.authorBonomi, Massimiliano
dc.contributor.authorVendruscolo, Michele
dc.date.accessioned2018-06-18T13:03:34Z
dc.date.available2018-06-18T13:03:34Z
dc.date.issued2018-08-03
dc.identifier.issn0022-2836
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/277169
dc.description.abstractOver the past decade, there has been a growing interest in investigating whether disordered proteins can be targeted for clinical purposes using small molecules [1-8]. While small-molecule binding to disordered proteins can be seen as unorthodox, examples of this phenomenon have been reported. In order to rationalize these observations, a variety of models are emerging, sometimes in apparent contradiction. Here, we offer a "structural ensemble modulation" view as an attempt to clarify the language, organize concepts, and facilitate the comparison of different studies. In doing so, we hope to promote the understanding of the general principles underlying this phenomenon toward the development of novel therapeutic compounds targeting disordered proteins, which are prevalent in a wide range of human diseases [1-8].
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectProteins
dc.subjectProtein Conformation
dc.subjectProtein Binding
dc.subjectMolecular Weight
dc.subjectEntropy
dc.subjectModels, Molecular
dc.subjectIntrinsically Disordered Proteins
dc.titleStructural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins.
dc.typeArticle
prism.endingPage2292
prism.issueIdentifier16
prism.publicationDate2018
prism.publicationNameJ Mol Biol
prism.startingPage2288
prism.volume430
dc.identifier.doi10.17863/CAM.24459
dcterms.dateAccepted2018-03-20
rioxxterms.versionofrecord10.1016/j.jmb.2018.03.015
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-08
dc.contributor.orcidHeller, Gabrielle [0000-0002-5672-0467]
dc.contributor.orcidBonomi, Massimilano [0000-0002-7321-0004]
dc.contributor.orcidVendruscolo, Michele [0000-0002-3616-1610]
dc.identifier.eissn1089-8638
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-03-26
cam.orpheus.successThu Jan 30 10:20:10 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International