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dc.contributor.authorNeumeyer, Sonja
dc.contributor.authorBanbury, Barbara L
dc.contributor.authorArndt, Volker
dc.contributor.authorBerndt, Sonja I
dc.contributor.authorBezieau, Stephane
dc.contributor.authorBien, Stephanie A
dc.contributor.authorBuchanan, Dan D
dc.contributor.authorButterbach, Katja
dc.contributor.authorCaan, Bette J
dc.contributor.authorCampbell, Peter T
dc.contributor.authorCasey, Graham
dc.contributor.authorChan, Andrew T
dc.contributor.authorChanock, Stephen J
dc.contributor.authorDai, James Y
dc.contributor.authorGallinger, Steven
dc.contributor.authorGiovannucci, Edward L
dc.contributor.authorGiles, Graham G
dc.contributor.authorGrady, William M
dc.contributor.authorHampe, Jochen
dc.contributor.authorHoffmeister, Michael
dc.contributor.authorHopper, John L
dc.contributor.authorHsu, Li
dc.contributor.authorJenkins, Mark A
dc.contributor.authorJoshi, Amit
dc.contributor.authorLarsson, Susanna C
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorLindblom, Annika
dc.contributor.authorMoreno, Victor
dc.contributor.authorLemire, Mathieu
dc.contributor.authorLi, Li
dc.contributor.authorLin, Yi
dc.contributor.authorOffit, Kenneth
dc.contributor.authorNewcomb, Polly A
dc.contributor.authorPharaoh, Paul D
dc.contributor.authorPotter, John D
dc.contributor.authorQi, Lihong
dc.contributor.authorRennert, Gad
dc.contributor.authorSchafmayer, Clemens
dc.contributor.authorSchoen, Robert E
dc.contributor.authorSlattery, Martha L
dc.contributor.authorSong, Mingyang
dc.contributor.authorUlrich, Cornelia M
dc.contributor.authorWin, Aung K
dc.contributor.authorWhite, Emily
dc.contributor.authorWolk, Alicja
dc.contributor.authorWoods, Michael O
dc.contributor.authorWu, Anna H
dc.contributor.authorGruber, Stephen B
dc.contributor.authorBrenner, Hermann
dc.contributor.authorPeters, Ulrike
dc.contributor.authorChang-Claude, Jenny
dc.date.accessioned2018-07-13T12:35:48Z
dc.date.available2018-07-13T12:35:48Z
dc.date.issued2018-06
dc.identifier.issn0007-0920
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/278091
dc.description.abstractBACKGROUND: Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on endogenous oestrogen exposure and CRC are inconsistent. METHODS: We used a Mendelian randomisation approach to test for a causal effect of age at menarche and age at menopause as surrogates for endogenous oestrogen exposure on CRC risk. Weighted genetic risk scores based on 358 single-nucleotide polymorphisms associated with age at menarche and 51 single-nucleotide polymorphisms associated with age at menopause were used to estimate the association with CRC risk using logistic regression in 12,944 women diagnosed with CRC and 10,741 women without CRC from three consortia. Sensitivity analyses were conducted to address pleiotropy and possible confounding by body mass index. RESULTS: Genetic risk scores for age at menarche (odds ratio per year 0.98, 95% confidence interval: 0.95-1.02) and age at menopause (odds ratio 0.98, 95% confidence interval: 0.94-1.01) were not significantly associated with CRC risk. The sensitivity analyses yielded similar results. CONCLUSIONS: Our study does not support a causal relationship between genetic risk scores for age at menarche and age at menopause and CRC risk.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.subjectHumans
dc.subjectColorectal Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectRegistries
dc.subjectLogistic Models
dc.subjectCase-Control Studies
dc.subjectAge Factors
dc.subjectMenopause
dc.subjectMenarche
dc.subjectPolymorphism, Single Nucleotide
dc.subjectFemale
dc.subjectMendelian Randomization Analysis
dc.titleMendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.
dc.typeArticle
prism.endingPage1647
prism.issueIdentifier12
prism.publicationDate2018
prism.publicationNameBr J Cancer
prism.startingPage1639
prism.volume118
dc.identifier.doi10.17863/CAM.25428
dcterms.dateAccepted2018-04-11
rioxxterms.versionofrecord10.1038/s41416-018-0108-8
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-06
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.identifier.eissn1532-1827
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-05-24
rioxxterms.freetoread.startdate2018-11-24


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