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dc.contributor.authorDatta, Deepankar
dc.contributor.authorConway Morris, Andrew
dc.contributor.authorAntonelli, Jean
dc.contributor.authorWarner, Noel
dc.contributor.authorBrown, Kenneth Alun
dc.contributor.authorWright, John
dc.contributor.authorSimpson, A John
dc.contributor.authorRennie, Jillian
dc.contributor.authorHulme, Gillian
dc.contributor.authorLewis, Sion Marc
dc.contributor.authorMare, Tracey Anne
dc.contributor.authorCookson, Sharon
dc.contributor.authorWeir, Christopher John
dc.contributor.authorDimmick, Ian
dc.contributor.authorKeenan, Jim
dc.contributor.authorRossi, Adriano Giorgio
dc.contributor.authorShankar-Hari, Manu
dc.contributor.authorWalsh, Timothy S
dc.contributor.authorExPRES Sepsis Investigators
dc.date.accessioned2018-07-18T08:51:47Z
dc.date.available2018-07-18T08:51:47Z
dc.date.issued2016-08-01
dc.identifier.issn2044-6055
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/278213
dc.description.abstractINTRODUCTION: Sepsis is an acute illness resulting from infection and the host immune response. Early identification of individuals at risk of developing life-threatening severe sepsis could enable early triage and treatment, and improve outcomes. Currently available biomarkers have poor predictive value for predicting subsequent clinical course in patients with suspected infection. Circulating leucocytes provide readily accessible tissues that reflect many aspects of the complex immune responses described in sepsis. We hypothesise that measuring cellular markers of immune responses by flow cytometry will enable early identification of infected patients at risk of adverse outcomes. We aim to characterise leucocyte surface markers (biomarkers) and their abnormalities in a population of patients presenting to the hospital emergency department with suspected sepsis, and explore their ability to predict subsequent clinical course. METHODS AND ANALYSIS: We will conduct a prospective, multicentre, clinical, exploratory, cohort observational study. To answer our study question, 3 patient populations will be studied. First, patients with suspected sepsis from the emergency department (n=300). To assess performance characteristics of potential tests, critically ill patients with established sepsis, and age and gender matched patients without suspicion of infection requiring hospital admission (both n=100) will be recruited as comparator populations. In all 3 groups, we plan to assess circulating biomarker profiles using flow cytometry. We will select candidate biomarkers by cross-cohort comparison, and then explore their predictive value for clinical outcomes within the cohort with suspected sepsis. ETHICS AND DISSEMINATION: The study will be carried out based on the principles in the Declaration of Helsinki and the International Conference on Harmonisation Good Clinical Practice. Ethics approval has been granted from the Scotland A Research Ethics Committee (REC) and Oxford C REC. On conclusion of this study, the results will be disseminated via peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT02188992; Pre-results.
dc.format.mediumElectronic
dc.languageeng
dc.publisherBMJ
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectExPRES Sepsis Investigators
dc.subjectLeukocytes
dc.subjectHumans
dc.subjectSepsis
dc.subjectCritical Illness
dc.subjectImmunologic Tests
dc.subjectHospitalization
dc.subjectProspective Studies
dc.subjectResearch Design
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectEmergency Service, Hospital
dc.subjectTriage
dc.subjectScotland
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.subjectBiomarkers
dc.titleEarly PREdiction of Severe Sepsis (ExPRES-Sepsis) study: protocol for an observational derivation study to discover potential leucocyte cell surface biomarkers.
dc.typeArticle
prism.issueIdentifier8
prism.publicationDate2016
prism.publicationNameBMJ Open
prism.startingPagee011335
prism.volume6
dc.identifier.doi10.17863/CAM.25557
dcterms.dateAccepted2016-06-09
rioxxterms.versionofrecord10.1136/bmjopen-2016-011335
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.licenseref.startdate2016-08
dc.contributor.orcidDatta, Deepankar [0000-0001-9971-9434]
dc.contributor.orcidConway Morris, Andrew [0000-0002-3211-3216]
dc.identifier.eissn2044-6055
rioxxterms.typeJournal Article/Review
cam.issuedOnline2016-08


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International