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dc.contributor.authorHughes, Katherineen
dc.contributor.authorWatson, Christineen
dc.date.accessioned2018-07-31T13:38:54Z
dc.date.available2018-07-31T13:38:54Z
dc.date.issued2018-08en
dc.identifier.issn0021-8782
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/278580
dc.description.abstractSinus-like dilatations of the mammary duct are recognisable in the mammary gland of pregnant and lactating wild European rabbits. These dilatations exhibit a bilaminar epithelial lining, with luminal epithelial cells expressing basal and lateral E-cadherin. Occasional binucleated mammary epithelial cells are present in the luminal layer. Underlying the luminal epithelial cells is a basal layer of cytokeratin 14-positive cells, supported by a thin layer of fibrous tissue. Multi-segmental epithelial proliferation, as indicated by Ki67 expression, is apparent in the luminal epithelial cells, suggesting a capacity for division during pregnancy and lactation. CD3-positive T lymphocytes are present both intraepithelially, suggesting exocytosis, and in foci subjacent to the ductular epithelium. We consider that sinus-like dilatations of the mammary duct may have the potential to give rise to a subset of the mammary gland neoplasms classified as ductal in origin. Milk accumulation in these sinus-like dilatations is likely to provide a niche for bacterial replication in cases of mastitis in rabbits. These structures are an important component of the innate immune system of the mammary gland, both as a physical barrier and as an interface between the milk and mammary immune cells.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherWiley-Blackwell
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMammary Glands, Animalen
dc.subjectT-Lymphocytesen
dc.subjectEpithelial Cellsen
dc.subjectAnimalsen
dc.subjectRabbitsen
dc.subjectKi-67 Antigenen
dc.subjectLactationen
dc.subjectPregnancyen
dc.subjectPregnancy, Animalen
dc.subjectFemaleen
dc.titleSinus-like dilatations of the mammary milk ducts, Ki67 expression, and CD3-positive T lymphocyte infiltration, in the mammary gland of wild European rabbits during pregnancy and lactation.en
dc.typeArticle
prism.endingPage273
prism.issueIdentifier2en
prism.publicationDate2018en
prism.publicationNameJournal of anatomyen
prism.startingPage266
prism.volume233en
dc.identifier.doi10.17863/CAM.25915
dcterms.dateAccepted2018-04-18en
rioxxterms.versionofrecord10.1111/joa.12824en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-08en
dc.contributor.orcidHughes, Katherine [0000-0002-3331-1249]
dc.contributor.orcidWatson, Christine [0000-0002-8548-5902]
dc.identifier.eissn1469-7580
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/J001023/1)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International