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dc.contributor.authorJepson, Marcusen
dc.contributor.authorElliott, Daisyen
dc.contributor.authorConefrey, Carmelen
dc.contributor.authorWade, Juliaen
dc.contributor.authorRooshenas, Leilaen
dc.contributor.authorWilson, Carolineen
dc.contributor.authorBeard, Daviden
dc.contributor.authorBlazeby, Jane Men
dc.contributor.authorBirtle, Alisonen
dc.contributor.authorHalliday, Alisonen
dc.contributor.authorStein, Roben
dc.contributor.authorDonovan, Jenny Len
dc.contributor.authorCSAW study group,en
dc.contributor.authorChemorad study group,en
dc.contributor.authorPOUT study group,en
dc.contributor.authorACST-2 study group,en
dc.contributor.authorOPTIMA prelim study group,en
dc.date.accessioned2018-08-23T09:31:01Z
dc.date.available2018-08-23T09:31:01Z
dc.date.issued2018-07en
dc.identifier.issn0895-4356
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/278987
dc.description.abstract© 2018 University of Bristol Objectives: To explore how the concept of randomization is described by clinicians and understood by patients in randomized controlled trials (RCTs) and how it contributes to patient understanding and recruitment. Study Design and Setting: Qualitative analysis of 73 audio recordings of recruitment consultations from five, multicenter, UK-based RCTs with identified or anticipated recruitment difficulties. Results: One in 10 appointments did not include any mention of randomization. Most included a description of the method or process of allocation. Descriptions often made reference to gambling-related metaphors or similes, or referred to allocation by a computer. Where reference was made to a computer, some patients assumed that they would receive the treatment that was “best for them”. Descriptions of the rationale for randomization were rarely present and often only came about as a consequence of patients questioning the reason for a random allocation. Conclusions: The methods and processes of randomization were usually described by recruiters, but often without clarity, which could lead to patient misunderstanding. The rationale for randomization was rarely mentioned. Recruiters should avoid problematic gambling metaphors and illusions of agency in their explanations and instead focus on clearer descriptions of the rationale and method of randomization to ensure patients are better informed about randomization and RCT participation.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCSAW study groupen
dc.subjectChemorad study groupen
dc.subjectPOUT study groupen
dc.subjectACST-2 study groupen
dc.subjectOPTIMA prelim study groupen
dc.titleAn observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded randomized clinical trial recruitment.en
dc.typeArticle
prism.endingPage83
prism.publicationDate2018en
prism.publicationNameJournal of clinical epidemiologyen
prism.startingPage75
prism.volume99en
dc.identifier.doi10.17863/CAM.26369
dcterms.dateAccepted2018-02-26en
rioxxterms.versionofrecord10.1016/j.jclinepi.2018.02.018en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-07en
dc.contributor.orcidWilson, Caroline [0000-0002-1678-7974]
dc.identifier.eissn1878-5921
rioxxterms.typeJournal Article/Reviewen


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)