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dc.contributor.authorHalliday, Marken
dc.contributor.authorMallucci, Giovannaen
dc.date.accessioned2018-09-05T12:41:03Z
dc.date.available2018-09-05T12:41:03Z
dc.date.issued2017-08en
dc.identifier.issn0006-8950
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279366
dc.description.abstractWe were interested to read the authors’ comments our recent paper in Brain (Halliday et al., 2017). We agree that carefully designed phase II and phase III trials would be needed to test the efficacy of trazodone as a treatment for neurodegeneration before use in human patients. However, it is also important to not underestimate the, potentially very significant, savings in both time and money that repurposing allows by skipping not only phase I trials, but also the arduous preclinical biochemistry, pharmacology, toxicology and medicinal chemistry needed for novel lead compounds. Hence, we do not feel we have overstated the potential of drug repurposing: there is an excellent premise for this in cancer, pain and other areas
dc.format.mediumPrinten
dc.languageengen
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnimalsen
dc.subjectMiceen
dc.subjectTrazodoneen
dc.subjectEukaryotic Initiation Factor-2en
dc.subjectProteomicsen
dc.subjectProtein Processing, Post-Translationalen
dc.titleReply: Trazodone to change the risk of neurodegeneration: bedside to bench.en
dc.typeArticle
prism.issueIdentifier8en
prism.publicationDate2017en
prism.publicationNameBrain : a journal of neurologyen
prism.startingPagee48
prism.volume140en
dc.identifier.doi10.17863/CAM.26743
rioxxterms.versionofrecord10.1093/brain/awx150en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-08en
dc.contributor.orcidMallucci, Giovanna [0000-0001-8504-1191]
dc.identifier.eissn1460-2156
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idAlzheimer's Drug Discovery Foundation (20141103)
pubs.funder-project-idECH2020 EUROPEAN RESEARCH COUNCIL (ERC) (647479)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)