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dc.contributor.authorHardcastle, Thomas J
dc.contributor.authorMüller, Sebastian Y
dc.contributor.authorBaulcombe, David C
dc.date.accessioned2018-09-05T12:47:32Z
dc.date.available2018-09-05T12:47:32Z
dc.date.issued2018-04-20
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279542
dc.description.abstractBased on 98 public and internal small RNA high throughput sequencing libraries, we mapped small RNAs to the genome of the model organism Arabidopsis thaliana and defined loci based on their expression using an empirical Bayesian approach. The resulting loci were subsequently classified based on their genetic and epigenetic context as well as their expression properties. We present the results of this classification, which broadly conforms to previously reported divisions between transcriptional and post-transcriptional gene silencing small RNAs, and to PolIV and PolV dependencies. However, we are able to demonstrate the existence of further subdivisions in the small RNA population of functional significance. Moreover, we present a framework for similar analyses of small RNA populations in all species.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectArabidopsis
dc.subjectArabidopsis Proteins
dc.subjectRNA, Small Interfering
dc.subjectRNA, Plant
dc.subjectBayes Theorem
dc.subjectEpigenesis, Genetic
dc.subjectGene Expression Regulation, Plant
dc.subjectRNA Interference
dc.subjectGenome, Plant
dc.subjectEpigenomics
dc.subjectHigh-Throughput Nucleotide Sequencing
dc.titleTowards annotating the plant epigenome: the Arabidopsis thaliana small RNA locus map.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameSci Rep
prism.startingPage6338
prism.volume8
dc.identifier.doi10.17863/CAM.26914
dcterms.dateAccepted2018-04-05
rioxxterms.versionofrecord10.1038/s41598-018-24515-8
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-04-20
dc.contributor.orcidMüller, Sebastian Y [0000-0002-0148-7020]
dc.contributor.orcidBaulcombe, David C [0000-0003-0780-6878]
dc.identifier.eissn2045-2322
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Research Council (340642)
cam.issuedOnline2018-04-20


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)