Show simple item record

dc.contributor.authorTarry-Adkins, Jane L
dc.contributor.authorAiken, Catherine
dc.contributor.authorAshmore, Thomas J
dc.contributor.authorTwinn, Denise
dc.contributor.authorChen, Jian-Hua
dc.contributor.authorOzanne, Susan
dc.date.accessioned2018-09-05T12:48:34Z
dc.date.available2018-09-05T12:48:34Z
dc.date.issued2019-01
dc.identifier.issn0892-6638
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279570
dc.description.abstractReduced fetal nutrition and rapid postnatal growth accelerates the aging phenotype in many organ systems; however, effects on the immune system are unclear. We addressed this by studying the thymus from a rat model of developmental programming. The recuperated group was generated by in utero protein restriction, followed by cross-fostering to control-fed mothers, and were then compared with controls. Fat infiltration and adipocyte size increased with age ( P < 0.001) and in recuperated thymi ( P < 0.05). Cortex/medulla ratio decreased with age ( P < 0.001) and decreased ( P < 0.05) in 12-mo recuperated thymi. Age-associated decreases in thymic-epithelial cell ( P < 0.01) and thymocyte markers ( P < 0.01) were observed in both groups and was decreased ( P < 0.05) in recuperated thymi. These data demonstrate effects of developmental programming upon thymic involution. The recuperated group had longer thymic telomeres than controls ( P < 0.001) at 22 d and at 3 mo, which was associated with increased expression of telomere-length maintenance molecules [telomerase RNA component ( Terc; P < 0.01), P23 ( P = 0.02), and Ku70 and Ku80 ( P < 0.01)]. By 12 mo, recuperated offspring had shorter thymic telomeres than controls had ( P < 0.001) and reduced DNA damage-response markers [( DNA-PKcs, Mre11 ( P < 0.01), Xrcc4 ( P = 0.02), and γ-H2ax ( P < 0.001], suggesting failure of earlier compensatory responses. Our results suggest that low birth weight with rapid postnatal growth results in premature thymic maturation, resulting in accelerated thymic aging. This could lead to increased age-associated vulnerability to infection.-Tarry-Adkins, J. L., Aiken, C. E., Ashmore, T. J., Fernandez-Twinn, D. S., Chen, J.-H., Ozanne, S. E. A suboptimal maternal diet combined with accelerated postnatal growth results in an altered aging profile in the thymus of male rats.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.subjectThymus Gland
dc.subjectAnimals
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectMalnutrition
dc.subjectDNA Damage
dc.subjectDiet
dc.subjectOxidative Stress
dc.subjectAging
dc.subjectFemale
dc.subjectMale
dc.subjectMaternal Nutritional Physiological Phenomena
dc.subjectTelomere Shortening
dc.subjectBiomarkers
dc.subjectCellular Senescence
dc.titleA suboptimal maternal diet combined with accelerated postnatal growth results in an altered aging profile in the thymus of male rats.
dc.typeArticle
prism.endingPage253
prism.issueIdentifier1
prism.publicationDate2019
prism.publicationNameFASEB J
prism.startingPage239
prism.volume33
dc.identifier.doi10.17863/CAM.26942
dcterms.dateAccepted2018-06-18
rioxxterms.versionofrecord10.1096/fj.201701350RR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-01
dc.contributor.orcidAiken, Catherine [0000-0002-6510-5626]
dc.contributor.orcidTwinn, Denise [0000-0003-2610-277X]
dc.contributor.orcidOzanne, Susan [0000-0001-8753-5144]
dc.identifier.eissn1530-6860
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idMedical Research Council (MC_UU_12012/4)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idMRC (MC_UU_00014/4)
pubs.funder-project-idBritish Heart Foundation (RG/17/12/33167)
cam.issuedOnline2018-07-05
cam.orpheus.successTue Feb 01 09:32:58 GMT 2022 - Embargo updated*
rioxxterms.freetoread.startdate2018-07-05


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record