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dc.contributor.authorWalker, Jennifer G
dc.contributor.authorMacrae, Finlay
dc.contributor.authorWinship, Ingrid
dc.contributor.authorOberoi, Jasmeen
dc.contributor.authorSaya, Sibel
dc.contributor.authorMilton, Shakira
dc.contributor.authorBickerstaffe, Adrian
dc.contributor.authorDowty, James G
dc.contributor.authorDe Abreu Lourenço, Richard
dc.contributor.authorClark, Malcolm
dc.contributor.authorGalloway, Louise
dc.contributor.authorFishman, George
dc.contributor.authorWalter, Fiona
dc.contributor.authorFlander, Louisa
dc.contributor.authorChondros, Patty
dc.contributor.authorAit Ouakrim, Driss
dc.contributor.authorPirotta, Marie
dc.contributor.authorTrevena, Lyndal
dc.contributor.authorJenkins, Mark A
dc.contributor.authorEmery, Jon D
dc.date.accessioned2018-09-05T12:51:26Z
dc.date.available2018-09-05T12:51:26Z
dc.date.issued2018-07-25
dc.identifier.issn1745-6215
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/279648
dc.description.abstractBACKGROUND: Australia and New Zealand have the highest incidence rates of colorectal cancer worldwide. In Australia there is significant unwarranted variation in colorectal cancer screening due to low uptake of the immunochemical faecal occult blood test, poor identification of individuals at increased risk of colorectal cancer, and over-referral of individuals at average risk for colonoscopy. Our pre-trial research has developed a novel Colorectal cancer RISk Prediction (CRISP) tool, which could be used to implement precision screening in primary care. This paper describes the protocol for a phase II multi-site individually randomised controlled trial of the CRISP tool in primary care. METHODS: This trial aims to test whether a standardised consultation using the CRISP tool in general practice (the CRISP intervention) increases risk-appropriate colorectal cancer screening compared to control participants who receive standardised information on cancer prevention. Patients between 50 and 74 years old, attending an appointment with their general practitioner for any reason, will be invited into the trial. A total of 732 participants will be randomised to intervention or control arms using a computer-generated allocation sequence stratified by general practice. The primary outcome (risk-appropriate screening at 12 months) will be measured using baseline data for colorectal cancer risk and objective health service data to measure screening behaviour. Secondary outcomes will include participant cancer risk perception, anxiety, cancer worry, screening intentions and health service utilisation measured at 1, 6 and 12 months post randomisation. DISCUSSION: This trial tests a systematic approach to implementing risk-stratified colorectal cancer screening in primary care, based on an individual's absolute risk, using a state-of-the-art risk assessment tool. Trial results will be reported in 2020. TRIAL REGISTRATION: Australian and New Zealand Clinical Trial Registry, ACTRN12616001573448p . Registered on 14 November 2016.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectColorectal Neoplasms
dc.subjectPrognosis
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectPredictive Value of Tests
dc.subjectDecision Support Techniques
dc.subjectTime Factors
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectPrimary Health Care
dc.subjectVictoria
dc.subjectFemale
dc.subjectMale
dc.subjectMulticenter Studies as Topic
dc.subjectRandomized Controlled Trials as Topic
dc.subjectClinical Trials, Phase II as Topic
dc.subjectEarly Detection of Cancer
dc.subjectGeneral Practice
dc.titleThe use of a risk assessment and decision support tool (CRISP) compared with usual care in general practice to increase risk-stratified colorectal cancer screening: study protocol for a randomised controlled trial.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameTrials
prism.startingPage397
prism.volume19
dc.identifier.doi10.17863/CAM.27016
dcterms.dateAccepted2018-06-25
rioxxterms.versionofrecord10.1186/s13063-018-2764-7
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-07-25
dc.contributor.orcidWalker, Jennifer G [0000-0002-6655-0940]
dc.contributor.orcidWalter, Fiona [0000-0002-7191-6476]
dc.identifier.eissn1745-6215
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-07-25


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)