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dc.contributor.authorMezquida, G
dc.contributor.authorSavulich, G
dc.contributor.authorGarcia-Rizo, C
dc.contributor.authorGarcia-Portilla, MP
dc.contributor.authorToll, A
dc.contributor.authorGarcia-Alvarez, L
dc.contributor.authorBobes, J
dc.contributor.authorMané, A
dc.contributor.authorBernardo, M
dc.contributor.authorFernandez-Egea, E
dc.date.accessioned2018-09-10T22:15:36Z
dc.date.available2018-09-10T22:15:36Z
dc.date.issued2018-02
dc.identifier.issn0920-9964
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280024
dc.description.abstractBACKGROUND: We investigated whether negative symptoms, such as poor motivation or anhedonia, were associated with higher body mass index (BMI) in stable patients with schizophrenia chronically treated with antipsychotic medication. METHODS: 62 olanzapine- or clozapine-treated patients with illness duration of at least four years were selected from an international multicenter study on the characterization of negative symptoms. All participants completed the Brief Negative Symptom Scale (BNSS) and the Positive and Negative Syndrome Scale (PANSS). Bivariate correlations between BMI and negative symptoms (BNSS) were explored, as well as multiple regression analyses. We further explored the association of two principal component factors of the BNSS and BMI. Subsidiary analyses re-modeled the above using the negative symptoms subscale of the PANSS and the EMSLEY factor for negative symptoms for convergent validity. RESULTS: Lower negative symptoms (BNSS score) were associated with higher BMI (r=-0.31; p=0.015). A multiple regression analysis showed that negative symptoms (BNSS score) and age were significant predictors of BMI (p=0.037). This was mostly driven by the motivation/pleasure factor of the BNSS. Within this second factor, BMI was negatively associated with anhedonia (r=-0.254; p=0.046) and asociality (r=-0.253; p=0.048), but not avolition (r=-0.169; p=0.188). EMSLEY score was positively associated with BNSS (r=0.873, p<0.001), but negatively associated with BMI (r=-0.308; p=0.015). The association between PANSS and BMI did not reach significance (r=-224, p=0.080). CONCLUSIONS: We conclude that lower negative symptoms were associated with higher BMI (assessed using both the BNSS and EMSLEY) in chronic stable schizophrenia patients, mostly due to lower anhedonia and asociality levels.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.subjectHumans
dc.subjectChronic Disease
dc.subjectBenzodiazepines
dc.subjectClozapine
dc.subjectAntipsychotic Agents
dc.subjectBody Mass Index
dc.subjectRegression Analysis
dc.subjectSchizophrenia
dc.subjectPsychiatric Status Rating Scales
dc.subjectSchizophrenic Psychology
dc.subjectAge Factors
dc.subjectPrincipal Component Analysis
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.subjectOlanzapine
dc.titleInverse association between negative symptoms and body mass index in chronic schizophrenia.
dc.typeArticle
prism.endingPage74
prism.publicationDate2018
prism.publicationNameSchizophr Res
prism.startingPage69
prism.volume192
dc.identifier.doi10.17863/CAM.27389
dcterms.dateAccepted2017-04-01
rioxxterms.versionofrecord10.1016/j.schres.2017.04.002
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-02
dc.contributor.orcidSavulich, G [0000-0002-6513-5454]
dc.contributor.orcidGarcia-Rizo, C [0000-0002-4855-1608]
dc.contributor.orcidBobes, J [0000-0003-2187-4033]
dc.contributor.orcidBernardo, M [0000-0001-8748-6717]
dc.identifier.eissn1573-2509
rioxxterms.typeJournal Article/Review
cam.issuedOnline2017-04-12
rioxxterms.freetoread.startdate2019-02-28


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