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dc.contributor.authorBaker, Clareen
dc.contributor.authorModrell, Melinda Sen
dc.date.accessioned2018-09-20T12:01:42Z
dc.date.available2018-09-20T12:01:42Z
dc.date.issued2018-08en
dc.identifier.issn1540-7063
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280393
dc.description.abstractThe vertebrate lateral line system comprises a mechanosensory division, with neuromasts containing hair cells that detect local water movement ("distant touch"); and an electrosensory division, with electrosensory organs that detect the weak, low-frequency electric fields surrounding other animals in water (primarily used for hunting). The entire lateral line system was lost in the amniote lineage with the transition to fully terrestrial life; the electrosensory division was lost independently in several lineages, including the ancestors of frogs and of teleost fishes. (Electroreception with different characteristics subsequently evolved independently within two teleost lineages.) Recent gene expression studies in a non-teleost actinopterygian fish suggest that electroreceptor ribbon synapses employ the same transmission mechanisms as hair cell ribbon synapses, and show that developing electrosensory organs express transcription factors essential for hair cell development, including Atoh1 and Pou4f3. Previous hypotheses for electroreceptor evolution suggest either that electroreceptors and hair cells evolved independently in the vertebrate ancestor from a common ciliated secondary cell, or that electroreceptors evolved from hair cells. The close developmental and putative physiological similarities implied by the gene expression data support the latter hypothesis, i.e., that electroreceptors evolved in the vertebrate ancestor as a "sister cell-type" to lateral line hair cells.
dc.format.mediumPrinten
dc.languageengen
dc.publisherOUP
dc.subjectAnimalsen
dc.subjectVertebratesen
dc.subjectGene Expression Regulation, Developmentalen
dc.subjectLateral Line Systemen
dc.subjectBiological Evolutionen
dc.titleInsights into Electroreceptor Development and Evolution from Molecular Comparisons with Hair Cells.en
dc.typeArticle
prism.endingPage340
prism.issueIdentifier2en
prism.publicationDate2018en
prism.publicationNameIntegrative and comparative biologyen
prism.startingPage329
prism.volume58en
dc.identifier.doi10.17863/CAM.27764
dcterms.dateAccepted2018-05-17en
rioxxterms.versionofrecord10.1093/icb/icy037en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-08en
dc.contributor.orcidBaker, Clare [0000-0002-4434-3107]
dc.identifier.eissn1557-7023
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/F00818X/1)
pubs.funder-project-idLeverhulme Trust (RPG-383)
rioxxterms.freetoread.startdate2019-06-11


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