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dc.contributor.authorDay, Felix R
dc.contributor.authorOng, Ken K
dc.contributor.authorPerry, John RB
dc.date.accessioned2018-09-20T12:03:23Z
dc.date.available2018-09-20T12:03:23Z
dc.date.issued2018-07-03
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280441
dc.description.abstractThe negative impacts of social isolation and loneliness on health are well documented. However, little is known about their possible biological determinants. In up to 452,302 UK Biobank study participants, we perform genome-wide association study analyses for loneliness and regular participation in social activities. We identify 15 genomic loci (P < 5 × 10-8) for loneliness, and demonstrate a likely causal association between adiposity and increased susceptibility to loneliness and depressive symptoms. Further loci were identified for regular attendance at a sports club or gym (N = 6 loci), pub or social club (N = 13) or religious group (N = 18). Across these traits there was strong enrichment for genes expressed in brain regions that control emotional expression and behaviour. We demonstrate aetiological mechanisms specific to each trait, in addition to identifying loci that are pleiotropic across multiple complex traits. Further study of these traits may identify novel modifiable risk factors associated with social withdrawal and isolation.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectRisk Factors
dc.subjectDepression
dc.subjectLoneliness
dc.subjectInterpersonal Relations
dc.subjectGenomics
dc.subjectPolymorphism, Single Nucleotide
dc.subjectGenome, Human
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.subjectGenome-Wide Association Study
dc.titleElucidating the genetic basis of social interaction and isolation.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameNat Commun
prism.startingPage2457
prism.volume9
dc.identifier.doi10.17863/CAM.27812
dcterms.dateAccepted2018-06-04
rioxxterms.versionofrecord10.1038/s41467-018-04930-1
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-07-03
dc.contributor.orcidDay, Felix R [0000-0003-3789-7651]
dc.contributor.orcidOng, Ken K [0000-0003-4689-7530]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/2)
cam.issuedOnline2018-07-03
datacite.issourceof.doi10.17863/CAM.23511


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International