Show simple item record

dc.contributor.authorNangalia, Jyoti
dc.contributor.authorGreen, Anthony R
dc.date.accessioned2018-09-20T12:04:41Z
dc.date.available2018-09-20T12:04:41Z
dc.date.issued2017-12-08
dc.identifier.issn1520-4391
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280478
dc.description.abstractSubstantial progress has been made in our understanding of the pathogenetic basis of myeloproliferative neoplasms. The discovery of mutations in JAK2 over a decade ago heralded a new age for patient care as a consequence of improved diagnosis and the development of therapeutic JAK inhibitors. The more recent identification of mutations in calreticulin brought with it a sense of completeness, with most patients with myeloproliferative neoplasm now having a biological basis for their excessive myeloproliferation. We are also beginning to understand the processes that lead to acquisition of somatic mutations and the factors that influence subsequent clonal expansion and emergence of disease. Extended genomic profiling has established a multitude of additional acquired mutations, particularly prevalent in myelofibrosis, where their presence carries prognostic implications. A major goal is to integrate genetic, clinical, and laboratory features to identify patients who share disease biology and clinical outcome, such that therapies, both existing and novel, can be better targeted.
dc.format.mediumPrint
dc.languageeng
dc.publisherAmerican Society of Hematology
dc.subjectAnimals
dc.subjectHumans
dc.subjectHematologic Neoplasms
dc.subjectMyeloproliferative Disorders
dc.subjectProtein Kinase Inhibitors
dc.subjectDNA Mutational Analysis
dc.subjectMyelopoiesis
dc.subjectMutation
dc.subjectJanus Kinase 2
dc.titleMyeloproliferative neoplasms: from origins to outcomes.
dc.typeArticle
prism.endingPage479
prism.issueIdentifier1
prism.publicationDate2017
prism.publicationNameHematology Am Soc Hematol Educ Program
prism.startingPage470
prism.volume2017
dc.identifier.doi10.17863/CAM.27849
rioxxterms.versionofrecord10.1182/asheducation-2017.1.470
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-12
dc.contributor.orcidNangalia, Jyoti [0000-0001-7122-4608]
dc.contributor.orcidGreen, Tony [0000-0002-9795-0218]
dc.identifier.eissn1520-4383
rioxxterms.typeJournal Article/Review
rioxxterms.freetoread.startdate2018-12-31


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record