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dc.contributor.authorLee, James
dc.date.accessioned2018-09-20T12:05:46Z
dc.date.available2018-09-20T12:05:46Z
dc.date.issued2017-12
dc.identifier.issn2059-2302
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280510
dc.description.abstractGenetic studies in complex diseases have been highly successful, but have also been largely one-dimensional: predominantly focusing on the genetic contribution to disease susceptibility. While this is undoubtedly important-indeed it is a pre-requisite for understanding the mechanisms underlying disease development-there are many other important aspects of disease biology that have received comparatively little attention. In this review, I will discuss how existing genetic data can be leveraged to provide new insights into other aspects of disease biology, why such insights could change the way we think about complex disease, and how this could provide opportunities for better therapies and/or facilitate personalised medicine. To do this, I will use the example of Crohn's disease-a chronic form of inflammatory bowel disease that has been one of the main success stories in complex disease genetics. Indeed, thanks to genetic studies, we now have a much more detailed understanding of the processes involved in Crohn's disease development, but still know relatively little about what determines the subsequent disease course (prognosis) and why this differs so considerably between individuals. I will discuss how we came to realise that genetic variation plays an important role in determining disease prognosis and how this has changed the way we think about Crohn's disease genetics. This will illustrate how phenotypic data can be used to leverage new insights from genetic data and will provide a broadly applicable framework that could yield new insights into the biology of multiple diseases.
dc.format.mediumPrint
dc.languageeng
dc.publisherWiley
dc.subjectHumans
dc.subjectCrohn Disease
dc.subjectGenetic Predisposition to Disease
dc.subjectGTP-Binding Proteins
dc.subjectPrognosis
dc.subjectSeverity of Illness Index
dc.subjectGene Expression Regulation
dc.subjectAlleles
dc.subjectGenome, Human
dc.subjectToll-Like Receptor 10
dc.subjectSmad3 Protein
dc.subjectNod2 Signaling Adaptor Protein
dc.subjectGenetic Variation
dc.subjectGenome-Wide Association Study
dc.subjectGenetic Loci
dc.subjectForkhead Box Protein O3
dc.titleBeyond disease susceptibility-Leveraging genome-wide association studies for new insights into complex disease biology.
dc.typeArticle
prism.endingPage334
prism.issueIdentifier6
prism.publicationDate2017
prism.publicationNameHLA
prism.startingPage329
prism.volume90
dc.identifier.doi10.17863/CAM.27880
dcterms.dateAccepted2017-10-31
rioxxterms.versionofrecord10.1111/tan.13170
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-12
dc.contributor.orcidLee, James [0000-0001-5711-9385]
dc.identifier.eissn2059-2310
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (105920/Z/14/Z)
cam.issuedOnline2017-11-20
rioxxterms.freetoread.startdate2018-12-31


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