Show simple item record

dc.contributor.authorPruijm, Menno
dc.contributor.authorMendichovszky, Iosif
dc.contributor.authorLiss, Per
dc.contributor.authorVan der Niepen, Patricia
dc.contributor.authorTextor, Stephen C
dc.contributor.authorLerman, Lilach O
dc.contributor.authorKrediet, CT Paul
dc.contributor.authorCaroli, Anna
dc.contributor.authorBurnier, Michel
dc.contributor.authorPrasad, Pottumarthi Vara
dc.date.accessioned2018-09-20T12:07:17Z
dc.date.available2018-09-20T12:07:17Z
dc.date.issued2018-09-01
dc.identifier.issn0931-0509
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280554
dc.description.abstractTissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation. BOLD-MRI has been validated against micropuncture techniques in animals. Its reproducibility has been demonstrated in humans, provided that physiological and technical conditions are standardized. BOLD-MRI has shown that patients suffering from chronic kidney disease (CKD) or kidneys with severe renal artery stenosis have lower tissue oxygenation than controls. Additionally, CKD patients with the lowest cortical oxygenation have the worst renal outcome. Finally, BOLD-MRI has been used to assess the influence of drugs on renal tissue oxygenation, and may offer the possibility to identify drugs with nephroprotective or nephrotoxic effects at an early stage. Unfortunately, different methods are used to prepare patients, acquire MRI data and analyse the BOLD images. International efforts such as the European Cooperation in Science and Technology (COST) action 'Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease' (PARENCHIMA) are aiming to harmonize this process, to facilitate the introduction of this technique in clinical practice in the near future. This article represents an extensive overview of the studies performed in this field, summarizes the strengths and weaknesses of the technique, provides recommendations about patient preparation, image acquisition and analysis, and suggests clinical applications and future developments.
dc.description.sponsorshipEU COST Action PARENCHIMA
dc.format.mediumPrint
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.subjectKidney
dc.subjectHumans
dc.subjectOxygen
dc.subjectMagnetic Resonance Imaging
dc.subjectOxygen Consumption
dc.subjectRenal Insufficiency, Chronic
dc.subjectPractice Guidelines as Topic
dc.subjectBiomarkers
dc.subjectHypoxia
dc.titleRenal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation: a statement paper and systematic review.
dc.typeArticle
prism.endingPageii28
prism.issueIdentifiersuppl_2
prism.publicationDate2018
prism.publicationNameNephrol Dial Transplant
prism.startingPageii22
prism.volume33
dc.identifier.doi10.17863/CAM.27922
dcterms.dateAccepted2018-06-27
rioxxterms.versionofrecord10.1093/ndt/gfy243
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-09
dc.contributor.orcidMendichovszky, Iosif [0000-0002-3777-2827]
dc.identifier.eissn1460-2385
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-08-23
rioxxterms.freetoread.startdate2019-09-30


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record