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dc.contributor.authorPearson, Craig S
dc.contributor.authorMencio, Caitlin P
dc.contributor.authorBarber, Amanda C
dc.contributor.authorMartin, Keith R
dc.contributor.authorGeller, Herbert M
dc.date.accessioned2018-09-20T12:07:48Z
dc.date.available2018-09-20T12:07:48Z
dc.date.issued2018-05-15
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280569
dc.description.abstractThe failure of mammalian CNS neurons to regenerate their axons derives from a combination of intrinsic deficits and extrinsic factors. Following injury, chondroitin sulfate proteoglycans (CSPGs) within the glial scar inhibit axonal regeneration, an action mediated by the sulfated glycosaminoglycan (GAG) chains of CSPGs, especially those with 4-sulfated (4S) sugars. Arylsulfatase B (ARSB) selectively cleaves 4S groups from the non-reducing ends of GAG chains without disrupting other, growth-permissive motifs. We demonstrate that ARSB is effective in reducing the inhibitory actions of CSPGs both in in vitro models of the glial scar and after optic nerve crush (ONC) in adult mice. ARSB is clinically approved for replacement therapy in patients with mucopolysaccharidosis VI and therefore represents an attractive candidate for translation to the human CNS.
dc.format.mediumElectronic
dc.languageeng
dc.publishereLife Sciences Publications, Ltd
dc.rightsCC0 No rights reserved
dc.subjectAxons
dc.subjectCells, Cultured
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectOptic Nerve Injuries
dc.subjectDisease Models, Animal
dc.subjectSulfates
dc.subjectN-Acetylgalactosamine-4-Sulfatase
dc.subjectTreatment Outcome
dc.subjectRegeneration
dc.subjectChondroitin Sulfate Proteoglycans
dc.titleIdentification of a critical sulfation in chondroitin that inhibits axonal regeneration.
dc.typeArticle
prism.publicationDate2018
prism.publicationNameElife
prism.volume7
dc.identifier.doi10.17863/CAM.27937
dcterms.dateAccepted2018-05-14
rioxxterms.versionofrecord10.7554/eLife.37139
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-05-15
dc.contributor.orcidPearson, Craig S [0000-0002-1906-6347]
dc.contributor.orcidGeller, Herbert M [0000-0002-7048-6144]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCambridge Eye Trust (unknown)
pubs.funder-project-idWellcome Trust (104001/Z/14/Z)
cam.issuedOnline2018-05-15


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