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dc.contributor.authorSmid, Marcel
dc.contributor.authorRodríguez-González, F Germán
dc.contributor.authorSieuwerts, Anieta M
dc.contributor.authorSalgado, Roberto
dc.contributor.authorPrager-Van der Smissen, Wendy JC
dc.contributor.authorVlugt-Daane, Michelle van der
dc.contributor.authorvan Galen, Anne
dc.contributor.authorNik-Zainal Abidin, Serena
dc.contributor.authorStaaf, Johan
dc.contributor.authorBrinkman, Arie B
dc.contributor.authorvan de Vijver, Marc J
dc.contributor.authorRichardson, Andrea L
dc.contributor.authorFatima, Aquila
dc.contributor.authorBerentsen, Kim
dc.contributor.authorButler, Adam
dc.contributor.authorMartin, Sancha
dc.contributor.authorDavies, Helen
dc.contributor.authorDebets, Reno
dc.contributor.authorGelder, Marion E Meijer-Van
dc.contributor.authorvan Deurzen, Carolien HM
dc.contributor.authorMacGrogan, Gaëtan
dc.contributor.authorVan den Eynden, Gert GGM
dc.contributor.authorPurdie, Colin
dc.contributor.authorThompson, Alastair M
dc.contributor.authorCaldas, Carlos
dc.contributor.authorSpan, Paul N
dc.contributor.authorSimpson, Peter T
dc.contributor.authorLakhani, Sunil R
dc.contributor.authorVan Laere, Steven
dc.contributor.authorDesmedt, Christine
dc.contributor.authorRingnér, Markus
dc.contributor.authorTommasi, Stefania
dc.contributor.authorEyford, Jorunn
dc.contributor.authorBroeks, Annegien
dc.contributor.authorVincent-Salomon, Anne
dc.contributor.authorFutreal, P Andrew
dc.contributor.authorKnappskog, Stian
dc.contributor.authorKing, Tari
dc.contributor.authorThomas, Gilles
dc.contributor.authorViari, Alain
dc.contributor.authorLangerød, Anita
dc.contributor.authorBørresen-Dale, Anne-Lise
dc.contributor.authorBirney, Ewan
dc.contributor.authorStunnenberg, Hendrik G
dc.contributor.authorStratton, Mike
dc.contributor.authorFoekens, John A
dc.contributor.authorMartens, John WM
dc.date.accessioned2018-09-29T06:09:41Z
dc.date.available2018-09-29T06:09:41Z
dc.date.issued2016-09-26
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/282958
dc.description.abstractA recent comprehensive whole genome analysis of a large breast cancer cohort was used to link known and novel drivers and substitution signatures to the transcriptome of 266 cases. Here, we validate that subtype-specific aberrations show concordant expression changes for, for example, TP53, PIK3CA, PTEN, CCND1 and CDH1. We find that CCND3 expression levels do not correlate with amplification, while increased GATA3 expression in mutant GATA3 cancers suggests GATA3 is an oncogene. In luminal cases the total number of substitutions, irrespective of type, associates with cell cycle gene expression and adverse outcome, whereas the number of mutations of signatures 3 and 13 associates with immune-response specific gene expression, increased numbers of tumour-infiltrating lymphocytes and better outcome. Thus, while earlier reports imply that the sheer number of somatic aberrations could trigger an immune-response, our data suggests that substitutions of a particular type are more effective in doing so than others.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleBreast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration.
dc.typeArticle
prism.publicationDate2016
prism.publicationNameNat Commun
prism.startingPage12910
prism.volume7
dc.identifier.doi10.17863/CAM.30321
dcterms.dateAccepted2016-08-15
rioxxterms.versionofrecord10.1038/ncomms12910
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-09-26
dc.contributor.orcidNik-Zainal Abidin, Serena [0000-0001-5054-1727]
dc.contributor.orcidCaldas, Carlos [0000-0003-3547-1489]
dc.contributor.orcidLakhani, Sunil R [0000-0003-1879-2555]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Commission (242006)
cam.issuedOnline2016-09-26


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International