Show simple item record

dc.contributor.authorFeitosa, Mary F
dc.contributor.authorKraja, Aldi T
dc.contributor.authorChasman, Daniel I
dc.contributor.authorSung, Yun J
dc.contributor.authorWinkler, Thomas W
dc.contributor.authorNtalla, Ioanna
dc.contributor.authorGuo, Xiuqing
dc.contributor.authorFranceschini, Nora
dc.contributor.authorCheng, Ching-Yu
dc.contributor.authorSim, Xueling
dc.contributor.authorVojinovic, Dina
dc.contributor.authorMarten, Jonathan
dc.contributor.authorMusani, Solomon K
dc.contributor.authorLi, Changwei
dc.contributor.authorBentley, Amy R
dc.contributor.authorBrown, Michael R
dc.contributor.authorSchwander, Karen
dc.contributor.authorRichard, Melissa A
dc.contributor.authorNoordam, Raymond
dc.contributor.authorAschard, Hugues
dc.contributor.authorBartz, Traci M
dc.contributor.authorBielak, Lawrence F
dc.contributor.authorDorajoo, Rajkumar
dc.contributor.authorFisher, Virginia
dc.contributor.authorHartwig, Fernando P
dc.contributor.authorHorimoto, Andrea RVR
dc.contributor.authorLohman, Kurt K
dc.contributor.authorManning, Alisa K
dc.contributor.authorRankinen, Tuomo
dc.contributor.authorSmith, Albert V
dc.contributor.authorTajuddin, Salman M
dc.contributor.authorWojczynski, Mary K
dc.contributor.authorAlver, Maris
dc.contributor.authorBoissel, Mathilde
dc.contributor.authorCai, Qiuyin
dc.contributor.authorCampbell, Archie
dc.contributor.authorChai, Jin Fang
dc.contributor.authorChen, Xu
dc.contributor.authorDivers, Jasmin
dc.contributor.authorGao, Chuan
dc.contributor.authorGoel, Anuj
dc.contributor.authorHagemeijer, Yanick
dc.contributor.authorHarris, Sarah E
dc.contributor.authorHe, Meian
dc.contributor.authorHsu, Fang-Chi
dc.contributor.authorJackson, Anne U
dc.contributor.authorKähönen, Mika
dc.contributor.authorKasturiratne, Anuradhani
dc.contributor.authorKomulainen, Pirjo
dc.contributor.authorKühnel, Brigitte
dc.contributor.authorLaguzzi, Federica
dc.contributor.authorLuan, Jian'an
dc.contributor.authorMatoba, Nana
dc.contributor.authorNolte, Ilja M
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorRiaz, Muhammad
dc.contributor.authorRueedi, Rico
dc.contributor.authorRobino, Antonietta
dc.contributor.authorSaid, M Abdullah
dc.contributor.authorScott, Robert A
dc.contributor.authorSofer, Tamar
dc.contributor.authorStančáková, Alena
dc.contributor.authorTakeuchi, Fumihiko
dc.contributor.authorTayo, Bamidele O
dc.contributor.authorvan der Most, Peter J
dc.contributor.authorVarga, Tibor V
dc.contributor.authorVitart, Veronique
dc.contributor.authorWang, Yajuan
dc.contributor.authorWare, Erin B
dc.contributor.authorWarren, Helen R
dc.contributor.authorWeiss, Stefan
dc.contributor.authorWen, Wanqing
dc.contributor.authorYanek, Lisa R
dc.contributor.authorZhang, Weihua
dc.contributor.authorZhao, Jing Hua
dc.contributor.authorAfaq, Saima
dc.contributor.authorAmin, Najaf
dc.contributor.authorAmini, Marzyeh
dc.contributor.authorArking, Dan E
dc.contributor.authorAung, Tin
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorBorecki, Ingrid
dc.contributor.authorBroeckel, Ulrich
dc.contributor.authorBrown, Morris
dc.contributor.authorBrumat, Marco
dc.contributor.authorBurke, Gregory L
dc.contributor.authorCanouil, Mickaël
dc.contributor.authorChakravarti, Aravinda
dc.contributor.authorCharumathi, Sabanayagam
dc.contributor.authorIda Chen, Yii-Der
dc.contributor.authorConnell, John M
dc.contributor.authorCorrea, Adolfo
dc.contributor.authorde Las Fuentes, Lisa
dc.contributor.authorde Mutsert, Renée
dc.contributor.authorde Silva, H Janaka
dc.contributor.authorDeng, Xuan
dc.contributor.authorDing, Jingzhong
dc.contributor.authorDuan, Qing
dc.contributor.authorEaton, Charles B
dc.contributor.authorEhret, Georg
dc.contributor.authorEppinga, Ruben N
dc.contributor.authorEvangelou, Evangelos
dc.contributor.authorFaul, Jessica D
dc.contributor.authorFelix, Stephan B
dc.contributor.authorForouhi, Nita
dc.contributor.authorForrester, Terrence
dc.contributor.authorFranco, Oscar H
dc.contributor.authorFriedlander, Yechiel
dc.contributor.authorGandin, Ilaria
dc.contributor.authorGao, He
dc.contributor.authorGhanbari, Mohsen
dc.contributor.authorGigante, Bruna
dc.contributor.authorGu, C Charles
dc.contributor.authorGu, Dongfeng
dc.contributor.authorHagenaars, Saskia P
dc.contributor.authorHallmans, Göran
dc.contributor.authorHarris, Tamara B
dc.contributor.authorHe, Jiang
dc.contributor.authorHeikkinen, Sami
dc.contributor.authorHeng, Chew-Kiat
dc.contributor.authorHirata, Makoto
dc.contributor.authorHoward, Barbara V
dc.contributor.authorIkram, M Arfan
dc.contributor.authorInterAct Consortium
dc.contributor.authorJohn, Ulrich
dc.contributor.authorKatsuya, Tomohiro
dc.contributor.authorKhor, Chiea Chuen
dc.contributor.authorKilpeläinen, Tuomas O
dc.contributor.authorKoh, Woon-Puay
dc.contributor.authorKrieger, José E
dc.contributor.authorKritchevsky, Stephen B
dc.contributor.authorKubo, Michiaki
dc.contributor.authorKuusisto, Johanna
dc.contributor.authorLakka, Timo A
dc.contributor.authorLangefeld, Carl D
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorLauner, Lenore J
dc.contributor.authorLehne, Benjamin
dc.contributor.authorLewis, Cora E
dc.contributor.authorLi, Yize
dc.contributor.authorLin, Shiow
dc.contributor.authorLiu, Jianjun
dc.contributor.authorLiu, Jingmin
dc.contributor.authorLoh, Marie
dc.contributor.authorLouie, Tin
dc.contributor.authorMägi, Reedik
dc.contributor.authorMcKenzie, Colin A
dc.contributor.authorMeitinger, Thomas
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorMilani, Lili
dc.contributor.authorMohlke, Karen L
dc.contributor.authorMomozawa, Yukihide
dc.contributor.authorNalls, Mike A
dc.contributor.authorNelson, Christopher P
dc.contributor.authorSotoodehnia, Nona
dc.contributor.authorNorris, Jill M
dc.contributor.authorO'Connell, Jeff R
dc.contributor.authorPalmer, Nicholette D
dc.contributor.authorPerls, Thomas
dc.contributor.authorPedersen, Nancy L
dc.contributor.authorPeters, Annette
dc.contributor.authorPeyser, Patricia A
dc.contributor.authorPoulter, Neil
dc.contributor.authorRaffel, Leslie J
dc.contributor.authorRaitakari, Olli T
dc.contributor.authorRoll, Kathryn
dc.contributor.authorRose, Lynda M
dc.contributor.authorRosendaal, Frits R
dc.contributor.authorRotter, Jerome I
dc.contributor.authorSchmidt, Carsten O
dc.contributor.authorSchreiner, Pamela J
dc.contributor.authorSchupf, Nicole
dc.contributor.authorScott, William R
dc.contributor.authorSever, Peter S
dc.contributor.authorShi, Yuan
dc.contributor.authorSidney, Stephen
dc.contributor.authorSims, Mario
dc.contributor.authorSitlani, Colleen M
dc.contributor.authorSmith, Jennifer A
dc.contributor.authorSnieder, Harold
dc.contributor.authorStarr, John M
dc.contributor.authorStrauch, Konstantin
dc.contributor.authorStringham, Heather M
dc.contributor.authorTan, Nicholas YQ
dc.contributor.authorTang, Hua
dc.contributor.authorTaylor, Kent D
dc.contributor.authorTeo, Yik Ying
dc.contributor.authorTham, Yih Chung
dc.contributor.authorTurner, Stephen T
dc.contributor.authorUitterlinden, André G
dc.contributor.authorVollenweider, Peter
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorWang, Lihua
dc.contributor.authorWang, Ya Xing
dc.contributor.authorWei, Wen Bin
dc.contributor.authorWilliams, Christine
dc.contributor.authorYao, Jie
dc.contributor.authorYu, Caizheng
dc.contributor.authorYuan, Jian-Min
dc.contributor.authorZhao, Wei
dc.contributor.authorZonderman, Alan B
dc.contributor.authorBecker, Diane M
dc.contributor.authorBoehnke, Michael
dc.contributor.authorBowden, Donald W
dc.contributor.authorChambers, John C
dc.contributor.authorDeary, Ian J
dc.contributor.authorEsko, Tõnu
dc.contributor.authorFarrall, Martin
dc.contributor.authorFranks, Paul W
dc.contributor.authorFreedman, Barry I
dc.contributor.authorFroguel, Philippe
dc.contributor.authorGasparini, Paolo
dc.contributor.authorGieger, Christian
dc.contributor.authorJonas, Jost Bruno
dc.contributor.authorKamatani, Yoichiro
dc.contributor.authorKato, Norihiro
dc.contributor.authorKooner, Jaspal S
dc.contributor.authorKutalik, Zoltán
dc.contributor.authorLaakso, Markku
dc.contributor.authorLaurie, Cathy C
dc.contributor.authorLeander, Karin
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorStudy, Lifelines Cohort
dc.contributor.authorMagnusson, Patrik KE
dc.contributor.authorOldehinkel, Albertine J
dc.contributor.authorPenninx, Brenda WJH
dc.contributor.authorPolasek, Ozren
dc.contributor.authorPorteous, David J
dc.contributor.authorRauramaa, Rainer
dc.contributor.authorSamani, Nilesh J
dc.contributor.authorScott, James
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorWagenknecht, Lynne E
dc.contributor.authorWareham, Nicholas
dc.contributor.authorWatkins, Hugh
dc.contributor.authorWeir, David R
dc.contributor.authorWickremasinghe, Ananda R
dc.contributor.authorWu, Tangchun
dc.contributor.authorZheng, Wei
dc.contributor.authorBouchard, Claude
dc.contributor.authorChristensen, Kaare
dc.contributor.authorEvans, Michele K
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHorta, Bernardo L
dc.contributor.authorKardia, Sharon LR
dc.contributor.authorLiu, Yongmei
dc.contributor.authorPereira, Alexandre C
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorRidker, Paul M
dc.contributor.authorvan Dam, Rob M
dc.contributor.authorGauderman, W James
dc.contributor.authorZhu, Xiaofeng
dc.contributor.authorMook-Kanamori, Dennis O
dc.contributor.authorFornage, Myriam
dc.contributor.authorRotimi, Charles N
dc.contributor.authorCupples, L Adrienne
dc.contributor.authorKelly, Tanika N
dc.contributor.authorFox, Ervin R
dc.contributor.authorHayward, Caroline
dc.contributor.authorvan Duijn, Cornelia M
dc.contributor.authorTai, E Shyong
dc.contributor.authorWong, Tien Yin
dc.contributor.authorKooperberg, Charles
dc.contributor.authorPalmas, Walter
dc.contributor.authorRice, Kenneth
dc.contributor.authorMorrison, Alanna C
dc.contributor.authorElliott, Paul
dc.contributor.authorCaulfield, Mark J
dc.contributor.authorMunroe, Patricia B
dc.contributor.authorRao, Dabeeru C
dc.contributor.authorProvince, Michael A
dc.contributor.authorLevy, Daniel
dc.date.accessioned2018-10-08T08:08:04Z
dc.date.available2018-10-08T08:08:04Z
dc.date.issued2018-06-18
dc.identifier.issn1932-6203
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283212
dc.description.abstractHeavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in ≈131K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P < 1.0 x 10-5). In Stage 2, these SNVs were tested for independent external replication in ≈440K individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10-8). For African ancestry samples, we detected 18 potentially novel BP loci (P < 5.0 x 10-8) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2) have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertension.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsCC0 1.0 Universal
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.titleNovel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
dc.typeArticle
prism.endingPagee0198166
prism.issueIdentifier6
prism.publicationDate2018
prism.publicationNamePLoS One
prism.startingPagee0198166
prism.volume13
dc.identifier.doi10.17863/CAM.30580
dcterms.dateAccepted2018-05-15
rioxxterms.versionofrecord10.1371/journal.pone.0198166
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2018-06-18
dc.contributor.orcidMarten, Jonathan [0000-0001-6916-2014]
dc.contributor.orcidLuan, Jian'an [0000-0003-3137-6337]
dc.contributor.orcidZhao, Jing Hua [0000-0003-4930-3582]
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.contributor.orcidLangenberg, Claudia [0000-0002-5017-7344]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.identifier.eissn1932-6203
dc.publisher.urlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198166
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idMedical Research Council (MC_UU_12015/5)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
pubs.funder-project-idMedical Research Council (MC_UU_12015/7)
cam.issuedOnline2018-06-18
dc.identifier.urlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198166


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC0 1.0 Universal
Except where otherwise noted, this item's licence is described as CC0 1.0 Universal